Benefits and drawbacks of guanidinoacetic acid as a possible treatment to replenish cerebral creatine in AGAT deficiency
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Summary
Guanidinoacetic acid (GAA), a direct metabolic precursor of creatine, has recently been suggested as a possible alternative to creatine to tackle brain creatine levels in experimental medicine.
- Type
- review
- Published
- 2017-10-03
- Cited by
- 10
- References
- 31
- OpenAlex
- https://openalex.org/W2763574516
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31593073
Keywords
Creatine, Hyperhomocysteinemia, Medicine, Arginine, Bioenergetics
References
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- Supplementation with Guanidinoacetic Acid in Women with Chronic Fatigue Syndrome
- The biochemical basis of betaine-glycocyamine therapy.
- Expression and function of AGAT, GAMT and CT1 in the mammalian brain.
- Effects of creatine precursors in arthritis; clinical and metabolic study of glycocyamine and betaine.
- Guanidinoacetic acid as a performance-enhancing agent
- Guanidinoacetate Is More Effective than Creatine at Enhancing Tissue Creatine Stores while Consequently Limiting Methionine Availability in Yucatan Miniature Pigs
- Arginine:glycine amidinotransferase (AGAT) deficiency: Clinical features and long term outcomes in 16 patients diagnosed worldwide.
- Guanidinoacetate administration increases acetylcholinesterase activity in striatum of rats and impairs retention of an inhibitory avoidance task
- Glycocyamine and betaine in motor-neurone disease.
- Expression and possible role of creatine transporter in the brain and at the blood‐cerebrospinal fluid barrier as a transporting protein of guanidinoacetate, an endogenous convulsant
- Mild guanidinoacetate increase under partial guanidinoacetate methyltransferase deficiency strongly affects brain cell development.
- Dose–response effects of oral guanidinoacetic acid on serum creatine, homocysteine and B vitamins levels
- Arginine:glycine amidinotransferase deficiency: the third inborn error of creatine metabolism in humans.
- AGAT, GAMT and SLC6A8 distribution in the central nervous system, in relation to creatine deficiency syndromes: A review
- Creatine and creatine deficiency syndromes: biochemical and clinical aspects.
- Betaine and glycocyamine in the treatment of poliomyelitis.
- γ-Aminobutyric Acid Transporter 2 Mediates the Hepatic Uptake of Guanidinoacetate, the Creatine Biosynthetic Precursor, in Rats
- The Metabolic Burden of Methyl Donor Deficiency with Focus on the Betaine Homocysteine Methyltransferase Pathway
- Creatine Metabolism and Safety Profiles after Six-Week Oral Guanidinoacetic Acid Administration in Healthy Humans
Cited by
- Metabolite Comparison between Serum and Follicular Fluid of Dairy Cows with Inactive Ovaries Postpartum
- Increased oxidative stress contributes to enhance brain amyloidogenesis and blunts energy metabolism in sucrose-fed rat: effect of AMPK activation
- A rare but treatable inborn error of metabolism: Arginine glycine amidinotransferase (AGAT) deficiency
- Safety of Dietary Guanidinoacetic Acid: A Villain of a Good Guy?
- Guanidinoacetic Acid Supplementation Promotes Skeletal Muscle Fiber Type Transformation from Fast-to-Slow-Twitch via Increasing the PPARGC1A Based Mitochondrial Function and CaN/NFAT Pathway in Finishing Pigs
- Creatine supplementation enhances immunological function of neutrophils by increasing cellular adenosine triphosphate
- Creatine Deficiency Disorders: Phenotypes, Genotypes, Diagnosis, and Treatment Outcomes
- Inborn Errors of Metabolism with Ataxia: Current and Future Treatment Options
- Guanidinoacetic Acid Supplementation: A Mechanistic Model of Utilization and Clearance
- INFORMATION PAPER ON CREATINE AND TRAUMATIC BRAIN INJURY
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