Mini-Review: The Contribution of Intermediate Phenotypes to GxE Effects on Disorders of Body Composition in the New OMICS Era
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Summary
With the successful characterization of phenomes, exposomes, and genomes, environmental and genetic determinants of chronic diseases can be united with multi-OMICS studies that better examine GxE interactions.
- Type
- review
- Published
- 2017-09-01
- Cited by
- 4
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W2755789607
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4393742
Keywords
Phenome, Exposome, Computational biology, Biology, Disease
References
- Systems Epidemiology: A New Direction in Nutrition and Metabolic Disease Research
- Using endophenotypes to examine molecules related to candidate genes as novel therapeutics: The "endophenotype-associated surrogate endpoint (EASE)" concept.
- Diabetes and Its Effect on Bone and Fracture Healing
- New Insights into Osteoporosis: The Bone-Fat Connection
- Genetic studies of common types of obesity: a critique of the current use of phenotypes
- Obesity: Friend or foe for osteoporosis
- Finding Our Way through Phenotypes
- Mechanisms of Disease: is osteoporosis the obesity of bone?
- ‘Deep phenotyping’: characterizing populations in the era of genomics and systems biology
- Gene–environment interactions in human diseases
- What We Talk About When We Talk About Fat
- The Role of Body Mass Index, Insulin, and Adiponectin in the Relation Between Fat Distribution and Bone Mineral Density
- Vitamin D: Link between Osteoporosis, Obesity, and Diabetes?
- Novel Insights into the Relationship between Diabetes and Osteoporosis
- Genetic epidemiology with a Capital E, ten years after
- Osteoporosis, Fractures, and Diabetes
- Gender Differences in Osteoporosis and Fractures
- Systems Biology Approaches and Applications in Obesity, Diabetes, and Cardiovascular Diseases
- Diving Through the “-Omics”: The Case for Deep Phenotyping and Systems Epidemiology
- Bone, fat, and body composition: evolving concepts in the pathogenesis of osteoporosis.
Cited by
- Congenital Leptin Deficiency and Leptin Gene Missense Mutation Found in Two Colombian Sisters with Severe Obesity
- Deconstructing ARDS Variability: Platelet Count, an ARDS Intermediate Phenotype and Novel Mediator of Genetic Effects in ARDS
- A Scoping Review Mapping the Effects of Environmental Factors on Obesity Comparative Analysis of Mexico and the United States
- Unifying the odyssey: artificial intelligence for rare disease diagnosis and therapy
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