Activation of a cryptic gene cluster in Lysobacter enzymogenes reveals a module/domain portable mechanism of nonribosomal peptide synthetases in the biosynthesis of pyrrolopyrazines
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Summary
Targeted gene inactivation showed that the two-module LedE and the one-module LedF were selectively used in pyrrolopyrazine biosynthesis, revealing a module/domain portable mechanism.
- Type
- article
- Published
- 2017-09-12
- Cited by
- 16
- References
- 21
- Access
- Open access
- OpenAlex
- https://openalex.org/W2754419068
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:42078048
Keywords
Nonribosomal peptide, Gene cluster, Gene, Biosynthesis, Peptide
References
- UNEXPECTED HYDROGENATION OF C-C-DOUBLE BONDS WITH TERT-BUTYL IODIDE
- Effect of single base substitutions at glycine-870 codon of gramicidin S synthetase 2 gene on proline activation.
- Involvement of both PKS and NRPS in antibacterial activity in Lysobacter enzymogenes OH11
- Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors.
- Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis.
- Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancers.
- Transcriptomic analysis reveals new regulatory roles of Clp signaling in secondary-metabolite biosynthesis and surface motility in Lysobacter enzymogenes OH11
- Antibiotics from neglected bacterial sources.
- BlmIII and BlmIV nonribosomal peptide synthetase-catalyzed biosynthesis of the bleomycin bithiazole moiety involving both in cis and in trans aminoacylation.
- Separation of WAP-8294A components, a novel anti-methicillin-resistant staphylococcus aureus antibiotic, using high-speed counter-current chromatography.
- Bioactive natural products from Lysobacter
- Nonribosomal peptide biosynthesis: point mutations and module skipping lead to chemical diversity.
- Cyclopiazonic Acid Biosynthesis in Aspergillus sp.: Characterization of a Reductase-like R* Domain in Cyclopiazonate Synthetase that Forms and Releases cyclo-Acetoacetyl-l-tryptophan
- Biosynthesis of HSAF, a Tetramic Acid-containing Macrolactam from Lysobacter enzymogenes
- Iterative Polyketide Biosynthesis by Modular Polyketide Synthases in Bacteria
- Structure and Biosynthesis of Heat-Stable Antifungal Factor (HSAF), a Broad-Spectrum Antimycotic with a Novel Mode of Action
- Iterative Assembly of Two Separate Polyketide Chains by the Same Single-module Bacterial Polyketide Synthase in the Biosynthesis of HSAF
- Lysobacter species: a potential source of novel antibiotics
- Identification and Characterization of the Anti-Methicillin-Resistant Staphylococcus aureus WAP-8294A2 Biosynthetic Gene Cluster from Lysobacter enzymogenes OH11
- Identification and Characterization of the Anti-Methicillin-Resistant Staphylococcus aureus WAP-8294A2 Biosynthetic Gene Cluster from Lysobacter enzymogenes OH11 (cid:1)
Cited by
- Natural products from thioester reductase containing biosynthetic pathways
- Nature’s combinatorial biosynthesis produces vatiamides A-F
- Identification of an Anti-MRSA Cyclic Lipodepsipeptide, WBP-29479A1, by Genome Mining of Lysobacter antibioticus.
- The rhizosphere signature on the cell motility, biofilm formation and secondary metabolite production of a plant-associated Lysobacter strain.
- Lysobacter enzymogenes LE16 autolysates have potential as biocontrol agents—Lysobacter sp. autolysates as biofungicide
- Identification of the biosynthetic gene cluster for the anti-MRSA lysocins through gene cluster activation using strong promoters of housekeeping genes and production of new analogs in Lysobacter sp. 3655.
- Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery
- Biosynthesis, regulation, and engineering of natural products from Lysobacter.
- PRODUCTION OF NEW WAP-8294A CYCLODEPSIPEPTIDES BY THE BIOLOGICAL CONTROL AGENT LYSOBACTER ENZYMOGENES OH11
- Comprehensive analysis of biosynthetic gene clusters in bacteria and discovery of Tumebacillus as a potential producer of natural products
- Lysohexaenetides A and B, linear lipopeptides from Lysobacter sp. DSM 3655 identified by heterologous expression in Streptomyces.
- Lysobacter enzymogenes: a fully armed biocontrol warrior1
- NRPS-like Gene LYS2 Contributed to the Biosynthesis of Cyclo(Pro-Val) in a Multistress-Tolerant Aromatic Probiotic, Meyerozyma guilliermondii GXDK6.
- Heterologous Production of Phenazines in the Biocontrol Agent Lysobacter enzymogenes C3.
- Erythromycin Stress Upregulates Antiangiogenic Metabolites in the Gut Bacterium Aneurinibacillus aneurinilyticus.
- Nature's Combinatorial Biosynthesis Produces Vatiamides A–F
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