Structure, mechanism, and regulation of polycomb-repressive complex 2
Explore this paper's citation graph
Summary
Recent studies elucidating the first crystal structures of the PRC2 core complex are examined, yielding seminal insights into its catalytic mechanism, substrate specificity, allosteric regulation, and inhibition by a class of small molecules that are currently undergoing cancer clinical trials.
- Type
- review
- Published
- 2017-09-14
- Cited by
- 72
- References
- 83
- Access
- Open access
- OpenAlex
- https://openalex.org/W2754413322
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205381074
Keywords
PRC2, Allosteric regulation, Epigenetics, Histone H3, Biology
References
- Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27.
- Mechanisms of Polycomb gene silencing: knowns and unknowns
- Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors
- Substrate Preferences of the EZH2 Histone Methyltransferase Complex*
- Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
- Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2.
- Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations
- Ring1b-mediated H2A Ubiquitination Associates with Inactive X Chromosomes and Is Involved in Initiation of X Inactivation*
- Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
- Polycomb: a paradigm for genome organization from one to three dimensions.
- EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
- The role of EZH2 in tumour progression
- Structure and function of histone methyltransferases.
- SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.
- Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors
- SET for life: biochemical activities and biological functions of SET domain-containing proteins
- Role of the polycomb protein Eed in the propagation of repressive histone marks
- Histone-modifying enzymes: encrypting an enigmatic epigenetic code.
- Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
- A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
Cited by
- Mammalian genomic regulatory regions predicted by utilizing human genomics, transcriptomics, and epigenetics data
- Epigenetic Targeting of Granulin in Hepatoma Cells by Synthetic CRISPR dCas9 Epi-suppressors
- From Flies to Mice: The Emerging Role of Non-Canonical PRC1 Members in Mammalian Development
- Clinical utility of EZH1 mutations in the diagnosis of follicular-patterned thyroid tumors.
- Towards the structural characterization of the human methyltransferome.
- Polycomb repressive complex 2 inhibitors: emerging epigenetic modulators.
- Automethylation-induced conformational switch in Clr4/Suv39h maintains epigenetic stability
- Introduction to the Thematic Minireview Series: Chromatin and transcription
- Genome-wide Prediction of Potential Polycomb Response Elements and their Functions
- Milestones in transcription and chromatin published in the Journal of Biological Chemistry
- Control of viral infections by epigenetic-targeted therapy
- Molecular Classification of Neuroendocrine Tumors of the Thymus.
- Off to a bad start: Cancer initiation by pluripotency regulator PRDM14
- Polycomb repressive 2 complex—Molecular mechanisms of function
- Inhibition of polycomb repressor complex 2 ameliorates neointimal hyperplasia by suppressing trimethylation of H3K27 in vascular smooth muscle cells
- Long noncoding RNA LINC-PINT promotes proliferation through EZH2 and predicts poor prognosis in clear cell renal cell carcinoma
- EZH2, JMJD3, and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells
- Identification of intermediate-sized deletions and inference of their impact on gene expression in a human population
- Signal Transduction in Diffuse Intrinsic Pontine Glioma
- EZH2, new diagnosis and prognosis marker in acute myeloid leukemia patients.
Related papers
- Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes
- Inner workings and regulatory inputs that control Polycomb repressive complex 2
- Inhibition of Polycomb Repressive Complex 2 activity reduces trimethylation of H3K27 and affects development in Arabidopsis seedlings
- Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma
- Structures of human PRC2 with its cofactors AEBP2 and JARID2
- Revolution in the Polycomb hierarchy
- Distinct stimulatory mechanisms regulate the catalytic activity of Polycomb Repressive Complex 2 (PRC2)
- Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity