Quercetin Declines Apoptosis, Ameliorates Mitochondrial Function and Improves Retinal Ganglion Cell Survival and Function in In Vivo Model of Glaucoma in Rat and Retinal Ganglion Cell Culture In Vitro
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Summary
It is found that Qcn not only improved RGC survival and function from a very early stage of COHT in vivo, it promoted the survival of hypoxia-treated primary cultured RGCs in vitro via ameliorating mitochondrial function and preventing mitochondria-mediated apoptosis.
- Type
- article
- Published
- 2017-09-07
- Cited by
- 46
- References
- 62
- Access
- Open access
- OpenAlex
- https://openalex.org/W2752347620
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6428938
Keywords
Neuroprotection, Retinal ganglion cell, In vivo, Apoptosis, Biology
References
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- Lenticular mitoprotection. Part A: Monitoring mitochondrial depolarization with JC-1 and artifactual fluorescence by the glycogen synthase kinase-3β inhibitor, SB216763
- [Recommendations of the Helsinki Declaration on clinical investigation and main guidelines in the care and use of animals].
- Crocin and Quercetin protect HCT116 and HEK293 cells from Zearalenone-induced apoptosis by reducing endoplasmic reticulum stress
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- Synergistic neuroprotection by epicatechin and quercetin: Activation of convergent mitochondrial signaling pathways.
- Neuroprotective and antioxidant effects of ghrelin in an experimental glaucoma model
- Pharmacologic modulation of acute ocular inflammation with quercetin.
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- Protective effects of glucosamine on oxidative-stress and ischemia/reperfusion-induced retinal injury.
- Regulation of the Intrinsic Apoptosis Pathway by Reactive Oxygen Species
- Decorin Prevents Retinal Pigment Epithelial Barrier Breakdown Under Diabetic Conditions by Suppressing p38 MAPK Activation.
- Effects of Spectral Characteristics of Ganzfeld Stimuli on the Photopic Negative Response (PhNR) of the ERG.
- Apoptosis of retinal ganglion cells in glaucoma: an update of the molecular pathways involved in cell death.
Cited by
- Comparative analysis of retinal ganglion cell damage in three glaucomatous rat models
- Neuroprotection in Glaucoma.
- Quercetin increases the antioxidant capacity of the ovary in menopausal rats and in ovarian granulosa cell culture in vitro
- Overexpression of Optic Atrophy Type 1 Protects Retinal Ganglion Cells and Upregulates Parkin Expression in Experimental Glaucoma
- Chemical and molecular characterization of metabolites from Flavobacterium sp.
- The Effect of Quercetin on Learning and Memory Deficit, Lipid Peroxidation, and Cholinesterase Activeity Following Lipopolysaccharide in the Rat
- Quercetin Enhances Inhibitory Synaptic Inputs and Reduces Excitatory Synaptic Inputs to OFF- and ON-Type Retinal Ganglion Cells in a Chronic Glaucoma Rat Model
- Quercetin protects the buffalo rat liver (BRL-3A) cells from aflatoxin B1-induced cytotoxicity via activation of Nrf2-ARE pathway
- Quercetin Attenuates the Oxidative Injury–Mediated Upregulation of Apoptotic Gene Expression and Catecholaminergic Neurotransmitters of the Fetal Rats’ Brain Following Prenatal Exposure to Fenitrothion Insecticide
- Mitochondrial Dysfunction as a Novel Target for Neuroprotective Nutraceuticals in Ocular Diseases
- Quercetin affects shoaling and anxiety behaviors in zebrafish: Involvement of neuroinflammation and neuron apoptosis.
- Inhibition of protein kinase R by C16 protects the retinal ganglion cells from hypoxia-induced oxidative stress, inflammation, and apoptosis.
- The therapeutic use of quercetin in ophthalmology: recent applications.
- Risk Factors for Retinal Ganglion Cell Distress in Glaucoma and Neuroprotective Potential Intervention
- The Potential of Lisosan G as a Possible Treatment for Glaucoma
- Glymphatic imaging and modulation of the optic nerve
- Quercetin decreases sterile inflammation proteins NLRP3 and caspase 1 in clone-9 cell line damaged by hydrogen peroxide
- RESTORING THE OXIDATIVE BALANCE IN AGE-RELATED DISEASES - AN APPROACH IN GLAUCOMA.
- Regulation of mitophagy by metformin improves the structure and function of retinal ganglion cells following excitotoxicity-induced retinal injury.
- Protective effects of quercetin in a rodent model of anterior ischemic optic neuropathy (rAION)
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