Metformin - its potential anti-cancer and anti-aging effects.
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Summary
The potential anti-cancer and anti-aging properties of metformin are described and the possible underlying mechanisms are discussed to help identify new targets for treatment of diabetes and metabolic syndrome.
- Type
- review
- Published
- 2017-03-02
- Cited by
- 170
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W2751676921
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27001247
Keywords
Metformin, AMPK, Protein kinase A, Adenosine monophosphate, Adenosine
References
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- Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling
- Methyl succinate antagonises biguanide‐induced AMPK‐activation and death of pancreatic β‐cells through restoration of mitochondrial electron transfer
- Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II
- Autophagy: Renovation of Cells and Tissues
- Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC
- Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.
- Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling
- Metformin, Independent of AMPK, Inhibits mTORC1 In a Rag GTPase-Dependent Manner
- Enhancing CD8 T Cell Memory by Modulating Fatty Acid Metabolism
- The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
- Autophagy and aging.
- The key role of growth hormone — insulin — IGF-1 signaling in aging and cancer
- Mitochondrial Stress: A Bridge between Mitochondrial Dysfunction and Metabolic Diseases?
- Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin–sensitizing effects of metformin
- Increasing healthy lifespan by suppressing aging in our lifetime: Preliminary proposal
- Mechanism for Fatty Acid “Sparing” Effect on Glucose-induced Transcription
- Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
- AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Cited by
- Association between periodontitis and the risk of palindromic rheumatism: A nationwide, population-based, case-control study
- Pharmacological Management of Gestational Diabetes Mellitus
- Identification of human age-associated gene co-expressions in functional modules using liquid association
- Biochemistry of Reactive Oxygen Species in Selective Cancer Cell Toxicity and Protection of Normal Cells
- Metformin increases urinary sodium excretion by reducing phosphorylation of the sodium-chloride cotransporter.
- Targeting Protein Quality Control Mechanisms by Natural Products to Promote Healthy Ageing
- Alpl prevents bone ageing sensitivity by specifically regulating senescence and differentiation in mesenchymal stem cells
- Major trauma and acceleration of the ageing process.
- The Association Between Diabetes and Cognitive Function in Later Life
- Effect of metformin on cell proliferation, apoptosis, migration and invasion in A172 glioma cells and its mechanisms
- Dual Inhibition of Pirarubicin-Induced AKT and ERK Activations by Phenformin Sensitively Suppresses Bladder Cancer Growth
- Early Onset Diabetes in Two Children due to Progeria, a Monogenic Disease of DNA Repair
- Metformin: A review of its therapeutic efficacy and adverse effects
- Metformin as Potential Therapy for High-Grade Glioma
- Metformin Potential Impact on the Growth of Vestibular Schwannomas.
- Protective effect of metformin against rotenone-induced parkinsonism in mice
- Metformin and Its Benefits for Various Diseases
- Identification of hub genes and small-molecule compounds in medulloblastoma by integrated bioinformatic analyses
- Metformin Prevents H2O2-Induced Senescence in Human Lens Epithelial B3 Cells
- Metabolism and Immune Modulation in Patients with Solid Tumors: Systematic Review of Preclinical and Clinical Evidence
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