Safety and efficacy of bi-annual intra-articular LBSA0103 injections in patients with knee osteoarthritis
Explore this paper's citation graph
Summary
Repeated intra-articular injection of high molecular weight hyaluronic acid at a 26-week interval is safe without increased risk of adverse drug reactions, and LBSA0103 is effective in reduction of osteoarthritis knee pain and in maintenance of pain reduction for a 39-week period when a second injection is administered.
- Type
- article
- Published
- 2017-11-01
- Cited by
- 9
- References
- 30
- Access
- Open access
- OpenAlex
- https://openalex.org/W2750119047
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9427464
Keywords
Medicine, Osteoarthritis, Adverse effect, Viscosupplementation, WOMAC
References
- Hyaluronic acid injections relieve knee pain.
- Comparative efficacy and safety of two different molecular weight (MW) hyaluronans F60027 and Hylan G-F20 in symptomatic osteoarthritis of the knee (KOA). Results of a non inferiority, prospective, randomized, controlled trial.
- Radiological Assessment of Osteo-Arthrosis
- Biochemical effects of two different hyaluronic acid products in a co-culture model of osteoarthritis.
- Modification and cross-linking parameters in hyaluronic acid hydrogels--definitions and analytical methods.
- Effects of different molecular weight elastoviscous hyaluronan solutions on articular nociceptive afferents.
- Therapeutic trajectory of hyaluronic acid versus corticosteroids in the treatment of knee osteoarthritis: a systematic review and meta-analysis.
- A Review of the Metabolism of 1,4-Butanediol Diglycidyl Ether–Crosslinked Hyaluronic Acid Dermal Fillers
- Differences between systematic reviews/meta-analyses of hyaluronic acid/hyaluronan/hylan in osteoarthritis of the knee.
- Viscosupplementation for Osteoarthritis of the Knee
- Osteoarthritis: Is viscosupplementation really so unsafe for knee OA?
- Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis.
- 99 CLEARANCE KINETICS OF A SINGLE INJECTION CROSSLINKED HYLAN-BASED VISCOSUPPLEMENT IN A RABBIT MODEL
- Intra-articular hyaluronan is without clinical effect in knee osteoarthritis: a multicentre, randomised, placebo-controlled, double-blind study of 337 patients followed for 1 year
- Hyaluronic acid counteracts interleukin-1-induced inhibition of collagen biosynthesis in cultured human chondrocytes.
- OMERACT-OARSI initiative: Osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited.
- Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association.
- Glucocorticosteroid therapy: mechanisms of action and clinical considerations.
- Pseudoseptic Reactions to Hylan Viscosupplementation: Diagnosis and Treatment
- Increased Frequency of Acute Local Reaction to Intra-Articular Hylan GF-20 (Synvisc) in Patients Receiving More Than One Course of Treatment
Cited by
- Intra-Articular Hyaluronic Acid in the Symptomatic Treatment of Knee Osteoarthritis: A Meta-Analysis of Single-Injection Products
- Injections intra articulaires (IA) d'acide hyaluronique (AH) dans le traitement symptomatique de la gonarthrose : une méta-analyse des injections uniques (mono-injections)
- Multimodal approach to intraarticular drug delivery in knee osteoarthritis
- Safety of a single intra-articular injection of LBSA0103 hyaluronic acid in patients with osteoarthritis of the knee: a multicenter, single-arm, prospective, cohort study
- Intra-Articular Injection of a Novel DVS Cross-Linked Hyaluronic Acid Manufactured by Biological Fermentation (YYD302) in Patients With Knee Osteoarthritis: A Double-Blind, Randomized, Multicenter, Noninferiority Study.
- Efficacy and Safety of Intra-Articular Cross-Linked Sodium Hyaluronate for the Treatment of Knee Osteoarthritis: A Prospective, Active-Controlled, Randomized, Parallel-Group, Double-Blind, Multicenter Study
- Safety and effectiveness of intra-articular injection of a highly cross-linked hyaluronic acid, LBSA0103 (Synovian): Results from a post-marketing surveillance study in South Korea
- Association between intra-articular hyaluronic acid injections in delaying total knee arthroplasty and safety evaluation in primary knee osteoarthritis: analysis based on Health Insurance Review and Assessment Service (HIRA) claim database in Republic of Korea
- Effect of repeated intra-articular administration of collagen as a treatment for knee osteoarthritis: a case report
- Efficacy of Intra-Articular Hyaluronic Acid Injections in Delaying Total Knee Arthroplasty and Safety Evaluation in Primary Knee Osteoarthritis: Analysis Based on Health Insurance Review and Assessment Service (HIRA) Claim Database in Korea
Related papers
- Hyaluronic Acid Viscosupplementation and Osteoarthritis
- Viscosupplementation of hyaluronic acid gels in case of osteoarthritis
- Hyaluronic Acid Injections for Knee Osteoarthritis
- A Review of the Clinical Effectiveness and Safety of Hybrid Cooperative Complexes in Intra-articular Viscosupplementation
- Biomedical applications and effect of hyaluronic acid as a filler material
- Viscosupplementation for osteoarthritis.
- Hybrid hyaluronic acid versus high molecular weight hyaluronic acid for the treatment of osteoarthritis in obese patients.
- Effectiveness of gonarthrosis treatment via intra-articular injections of linear vs. cross-linked hyaluronic acids