Lactate dehydrogenase activity drives hair follicle stem cell activation
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Summary
It is demonstrated that HFSCs utilize glycolytic metabolism and produce significantly more lactate than other cells in the epidermis, and small molecules that increase lactate production by stimulating Myc levels or inhibiting Mpc1 carrier activity and can topically induce the hair cycle are identified.
- Type
- article
- Published
- 2017-08-14
- Cited by
- 266
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W2749736089
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3298553
Keywords
Cell biology, Hair follicle, Glycolysis, Lactate dehydrogenase, Biology
References
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- Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles
Cited by
- Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism
- Topical inhibition of the electron transport chain can stimulate the hair cycle
- The impact of cellular metabolism on chromatin dynamics and epigenetics
- Cell fate decisions: emerging roles for metabolic signals and cell morphology
- Mitochondrial activity in the regulation of stem cell self-renewal and differentiation.
- A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity.
- Stem Cell Metabolism in Cancer and Healthy Tissues: Pyruvate in the Limelight
- Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair
- Metabolism in pluripotency: Both driver and passenger?
- The force is strong with this one: Metabolism (over)powers stem cell fate
- Postmenopausaler Lichen planopilaris alias fibrosierende frontotemporale Alopezie Kossard
- Epigenetic regulation of cell fate reprogramming in aging and disease: A predictive computational model
- Fasting activates Fatty Acid Oxidation to enhance intestinal stem cell function during homeostasis and aging
- Skin Cell Heterogeneity in Development, Wound Healing, and Cancer
- Metabolic regulation of chromatin modifications and gene expression
- miR-339-5p negatively regulates loureirin A-induced hair follicle stem cell differentiation by targeting DLX5
- Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue.
- Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development
- Effect of lactate dehydrogenase activity on hair follicle stem cell
- Investigation into the molecular mechanisms of congenital insensitivity to pain
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