Learning the Roles of the Hepatic Adaptive Immune System in Hepatocellular Carcinoma—Nature's Guide for Successful Cancer Immunotherapy
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Summary
It is not surprising that malignant hepatocytes interact extensively with adaptive immune cells, resulting in both protumor immunopathology and antitumor protective immunity in hepatocellular carcinoma.
- Type
- review
- Published
- 2017-08-01
- Cited by
- 4
- References
- 80
- OpenAlex
- https://openalex.org/W2749015124
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12947185
Keywords
Immune system, Immunotherapy, Acquired immune system, Hepatocellular carcinoma, Immunology
References
- Inflammatory tumour microenvironment is associated with superior survival in hepatocellular carcinoma patients.
- Quantitative Effect of Natural Killer–Cell Licensing on Hepatocellular Carcinoma Recurrence after Curative Hepatectomy
- Biological functions of regulatory T cells.
- Activation and dramatically increased cytolytic activity of tumor specific T lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases.
- PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
- Tumor‐infiltrating, interleukin‐33–producing effector‐memory CD8+ T cells in resected hepatocellular carcinoma prolong patient survival
- Intrahepatic interleukin‐17+ T cells and FoxP3+ regulatory T cells cooperate to promote development and affect the prognosis of hepatocellular carcinoma
- IL-33 Facilitates Oncogene Induced Cholangiocarcinoma in Mice by an IL-6 Sensitive Mechanism
- Liver tumor infiltrating lymphocytes: comparison of hepatocellular and cholangiolar carcinoma.
- Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma
- Clinicopathological study on hepatocellular carcinoma with lymphocytic infiltration
- Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance
- Intratumoral regulatory T cells alone or in combination with cytotoxic T cells predict prognosis of hepatocellular carcinoma after resection
- A lymphotoxin-driven pathway to hepatocellular carcinoma
- Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout
- Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients.
- Natural Killer Cells in Liver Disease
- Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes.
- Roles of Tregs in development of hepatocellular carcinoma: a meta-analysis.
- 12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy?
Cited by
- The AT1/Raf/ERK1/2 signaling pathway is involved in Angiotensin II-enhanced proliferation of hepatic carcinoma cells.
- Characterization of HCC Mouse Models: Towards an Etiology-Oriented Subtyping Approach
- Design, synthesis and biological evaluation of benzamide derivatives as novel NTCP inhibitors that induce apoptosis in HepG2 cells.
- HLA‐G 3′UTR haplotype analyses in HCV infection and HCV‐derived cirrhosis, hepatocellular carcinoma and fibrosis
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