Baicalin Ameliorates Liver Injury Induced by Chronic plus Binge Ethanol Feeding by Modulating Oxidative Stress and Inflammation via CYP2E1 and NRF2 in Mice
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Summary
It is suggested that baicalin ameliorates chronic plus binge ethanol-induced liver injury involving molecular crosstalk of multiple pathways at the transcriptional level and through upregulation of antioxidant defense mechanism.
- Type
- article
- Published
- 2017-08-16
- Cited by
- 67
- References
- 49
- Access
- Open access
- OpenAlex
- https://openalex.org/W2748952176
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20084918
Keywords
Oxidative stress, CYP2E1, Inflammation, Ethanol, Liver injury
References
- Glycycoumarin ameliorates alcohol-induced hepatotoxicity via activation of Nrf2 and autophagy.
- Apoptosis and Necrosis in the Liver
- Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalin
- Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways
- Baicalin improves antioxidant status of streptozotocin-induced diabetic Wistar rats.
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- Baicalein modulates Nrf2/Keap1 system in both Keap1-dependent and Keap1-independent mechanisms.
- Protective effect of baicalin against carbon tetrachloride-induced acute hepatic injury in mice.
- Nutritional strategies to modulate inflammation and oxidative stress pathways via activation of the master antioxidant switch Nrf2.
- Baicalin Attenuates High Fat Diet-Induced Obesity and Liver Dysfunction: Dose-Response and Potential Role of CaMKKβ/AMPK/ACC Pathway
- Mouse model of chronic and binge ethanol feeding (the NIAAA model)
- Chronic plus Binge Ethanol Feeding Synergistically Induces Neutrophil Infiltration and Liver Injury: a Critical Role for E-selectin
- Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis
- The involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity.
- Ameliorative Effect of Fisetin on Cisplatin-Induced Nephrotoxicity in Rats via Modulation of NF-κB Activation and Antioxidant Defence
- Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets
- CYP2E1 and oxidative liver injury by alcohol.
- Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: Role of STAT3
- Absorption and enterohepatic circulation of baicalin in rats.
- Baicalin protects mouse from Concanavalin A‐induced liver injury through inhibition of cytokine production and hepatocyte apoptosis
Cited by
- Baicalin exerts protective effects against lipopolysaccharide-induced acute lung injury by regulating the crosstalk between the CX3CL1-CX3CR1 axis and NF-κB pathway in CX3CL1-knockout mice
- Polydatin Protects Rat Liver against Ethanol-Induced Injury: Involvement of CYP2E1/ROS/Nrf2 and TLR4/NF-κB p65 Pathway
- Baicalein and baicalin alleviate acetaminophen‐induced liver injury by activating Nrf2 antioxidative pathway: The involvement of ERK1/2 and PKC
- Targeting Nrf-2 is a promising intervention approach for the prevention of ethanol-induced liver disease
- Aqueous Extract of Pepino (Solanum muriactum Ait) Leaves Ameliorate Lipid Accumulation and Oxidative Stress in Alcoholic Fatty Liver Disease
- Baicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway
- Baicalin regulates SirT1/STAT3 pathway and restrains excessive hepatic glucose production
- Nrf2 in alcoholic liver disease
- Synergistic enhancement and hepatoprotective effect of combination of total phenolic extracts of Citrus aurantium L. and methotrexate for treatment of rheumatoid arthritis
- Nuciferine alleviates acute alcohol-induced liver injury in mice: Roles of suppressing hepatic oxidative stress and inflammation via modulating miR-144/Nrf2/HO-1 cascade
- In vitro and in vivo activities of flavonoids – apigenin, baicalin, chrysin, scutellarin – in regulation of hypertension – a review for their possible effects in pregnancy-induced hypertension
- Aldose Reductase Inhibitors of Plant Origin in the Prevention and Treatment of Alcoholic Liver Disease: A Minireview
- Baicalin ameliorates lipopolysaccharide-induced acute lung injury in mice by suppressing oxidative stress and inflammation via the activation of the Nrf2-mediated HO-1 signaling pathway
- Bailcalin Protects against Diabetic Cardiomyopathy through Keap1/Nrf2/AMPK-Mediated Antioxidative and Lipid-Lowering Effects
- Baicalin relieves inflammation stimulated by lipopolysaccharide via upregulating TUG1 in liver cells
- γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
- Natural Products, extracts and formulations comprehensive therapy for the improvement of motor function in Alcoholic liver disease.
- Baicalin suppress growth and virulence-related factors of methicillin-resistant Staphylococcus aureus in vitro and vivo.
- Aronia melanocarpa Prevents Alcohol-Induced Chronic Liver Injury via Regulation of Nrf2 Signaling in C57BL/6 Mice
- Natural products for the prevention and treatment of cholestasis: A review
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