Immunomodulatory Effect of G2013 (α-L-Guluronic Acid) on the TLR2 and TLR4 in Human Mononuclear Cells.
Explore this paper's citation graph
Summary
The findings point to the immunomodulatory effect of G2013 on the TLR2 and TLR4 signaling cascade and cytokine production by PBMCs that could lead to the establishment of new safe anti-inflammatory drugs in the future.
- Type
- article
- Published
- 2018-05-31
- Cited by
- 20
- References
- 0
- OpenAlex
- https://openalex.org/W2743141330
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13955886
Keywords
TLR2, TLR4, Peripheral blood mononuclear cell, Receptor, Lipopolysaccharide
References
No references recorded for this paper.
Cited by
- The Inhibitory Role of M2000 (β-D-Mannuronic Acid) on Expression of Toll-like Receptor 2 and 4 in HT29 Cell Line
- The Immunomodulatory Role of G2013 (α-L-Guluronic Acid) on the Expression of TLR2 and TLR4 in HT29 cell line.
- Toll-Like Receptor 2 Signaling and Current Approaches for Therapeutic Modulation in Synucleinopathies
- Nystatin enhances the immune response against Candida albicans and protects the ultrastructure of the vaginal epithelium in a rat model of vulvovaginal candidiasis
- Assessment of immunological profile in ankylosing spondylitis patients following a clinical trial with guluronic acid (G2013), as a new NSAID with immunomodulatory properties
- A randomized clinical trial for the assessment of the efficacy and safety of guluronic acid (G2013) in patients with rheumatoid arthritis
- A Review of Preclinical Experiments Toward Targeting M2 Macrophages in Prostate Cancer.
- بررسی اثر باکتریهای پروبیوتیک لاکتوباسیلوس اسیدوفیلوس PTCC1643 و لاکتوباسیلوس کازیی PTCC 1608 بر روی بیان ژنهای TLR2 و TLR4 در سلولهای HT29 عفونی شده با سالمونلا انتریتیدیس
- Co‐expression of TLR‐9 and MMP‐13 is associated with the degree of tumour differentiation in prostate cancer
- Effects of guluronic acid (G2013) on gene expression of TLR2, TLR4, MyD88, TNF-α and CD52 in multiple sclerosis under in vitro conditions
- Pivotal cytokines and their transcription factors are the targets of guluronic acid (G2013) for inhibiting the immunopathogenesis process of multiple sclerosis
- Advances in Research on the Bioactivity of Alginate Oligosaccharides
- Evaluation of the oral administration of α‐l‐guluronic acid on COX‐1 and COX‐2 gene expression profile in ankylosing spondylitis patients
- Anti-tumor effect of M2000 (β-d-mannuronic acid) on the expression of inflammatory molecules in the prostate cancer cell
- The effects of guluronic acid (G2013), a new emerging treatment, on inflammatory factors in nonalcoholic steatohepatitis patients under in vitro conditions
- Evaluation of G2013 (α‐L‐guluronic acid) efficacy on PC‐3 cells through inhibiting the expression of inflammatory factors
- Immuno-modulatory biomaterials as anti-inflammatory therapeutics.
- Polyguluronic acid alleviates doxorubicin-induced cardiotoxicity by suppressing Peli1-NLRP3 inflammasome-mediated pyroptosis.
- An Overview on the Function of Probiotics and Their Positive Effects on Enhancing Intestinal Immune Responses
- The IL‐23/IL‐17/NF‐κB Signaling Pathway in Rheumatoid Arthritis: Molecular Mechanisms and Therapeutic Agents
Related papers
- Besides TLR2 and TLR4, NLRP3 is also involved in regulating Escherichia coli infection-induced inflammatory responses in mice
- Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activation.
- Toll-Like Receptor 4, But Not Toll-Like Receptor 2, Is a Signaling Receptor for Escherichia and Salmonella Lipopolysaccharides1
- Gene Expressions of Toll-Like Receptor 2, But Not Toll-Like Receptor 4, Is Induced by LPS and Inflammatory Cytokines in Mouse Macrophages1
- Signaling by Toll-Like Receptor 2 and 4 Agonists Results in Differential Gene Expression in Murine Macrophages
- Besides TLR2 and TLR4, NLRP3 is also involved in regulating Escherichia coli infection-induced inflammatory responses in mice.
- TLR4-Independent Effects of LPS Identified Using Longitudinal Serum Proteomics
- TOLL-LIKE RECEPTORS (TLR) 2 AND 4 EXPRESSION OF KERATINOCYTES FROM PATIENTS WITH LOCALIZED AND DISSEMINATED DERMATOPHYTOSIS