A review on protein misfolding, aggregation and strategies to prevent related ailments.
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Summary
This review has shed light on the mechanism of protein misfolding which leads to its aggregation and hence the neurodegeneration and the possibility that protein aggregation may be exploited by nature to perform specific physiological functions in differing biological contexts.
- Type
- review
- Published
- 2017-12-01
- Cited by
- 46
- References
- 124
- OpenAlex
- https://openalex.org/W2736745580
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25329037
Keywords
Protein aggregation, Neurodegeneration, Mechanism (biology), Protein folding, Disease
References
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Cited by
- Protective Roles of Intestinal Microbiota derived Short Chain Fatty Acids in Alzheimer’s Disease-type Beta-Amyloid Neuropathological Mechanisms
- Protein heterogeneity and the immunogenicity of biotherapeutics.
- Heterogeneity in gut microbiota drive polyphenol metabolism that influences α-synuclein misfolding and toxicity
- Protein Misfolding and ER Stress in Huntington's Disease
- Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts
- Caffeine destabilizes preformed Aβ protofilaments: insights from all atom molecular dynamics simulations.
- Ellagic acid can act as a chaperone and suppress the heat-induced amyloid-like aggregation of ovalbumin
- Multivariate optimization of the refolding process of an incorrectly folded Fc-fusion protein in cell culture broth.
- Ligand-induced disorder-to-order transitions characterized by structural proteomics and molecular dynamics simulations
- Role of Pre-molten Globule Structure in Protein Amyloid Fibril Formation
- Drosophila NUAK functions with Starvin/BAG3 in autophagic protein turnover
- Flavonoids as Potential Drugs for VPS13-Dependent Rare Neurodegenerative Diseases
- Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization
- Destabilization potential of phenolics on Aβ fibrils: mechanistic insights from molecular dynamics simulation.
- High-Throughput Screening Platforms in the Discovery of Novel Drugs for Neurodegenerative Diseases
- Post-translational modifications: Regulators of neurodegenerative proteinopathies.
- Recent advances on drug development and emerging therapeutic agents for Alzheimer’s disease
- Emerging role of metabolomics in protein conformational disorders
- Spectroscopic studies on the stability and nucleation-independent fibrillation of partially-unfolded proteins in crowded environment.
- Zebrafish an experimental model of Huntington’s disease: molecular aspects, therapeutic targets and current challenges
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