Interferon-Stimulated Genes are Transcriptionally Repressed by PR in Breast Cancer
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Summary
This study identifies a novel transcriptional mechanism through which PR drives breast cancer development and potentially evades the immune system through ligand-activated PR-dependent downregulation of IFN signaling.
- Type
- article
- Published
- 2017-07-06
- Cited by
- 29
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W2727632236
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6633264
Keywords
Cancer research, Biology, Gene knockdown, Psychological repression, Transcriptional regulation
References
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- Estrogen control of progesterone receptor induction in human breast cancer: role of nuclear estrogen receptor.
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- New T47D breast cancer cell lines for the independent study of progesterone B- and A-receptors: only antiprogestin-occupied B-receptors are switched to transcriptional agonists by cAMP.
- An interferon signature identified by RNA-sequencing of mammary tissues varies across the estrous cycle and is predictive of metastasis-free survival
- Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape
- Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes
- Scaffolding actions of membrane-associated progesterone receptors
- Role of Phosphorylation in Progesterone Receptor Signaling and Specificity
- Estrogen receptor target gene: an evolving concept.
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- Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
- A Common Docking Domain in Progesterone Receptor-B links DUSP6 and CK2 signaling to proliferative transcriptional programs in breast cancer cells
- Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes.
- Factorbook.org: a Wiki-based database for transcription factor-binding data generated by the ENCODE consortium
- An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer
- Chromatin Dynamics of Gene Activation and Repression in Response to Interferon α (IFNα) Reveal New Roles for Phosphorylated and Unphosphorylated Forms of the Transcription Factor STAT2*
- Progesterone signalling in breast cancer: a neglected hormone coming into the limelight
Cited by
- O-GlcNAc-dependent regulation of progesterone receptor function in breast cancer
- Revisiting progesterone receptor (PR) actions in breast cancer: Insights into PR repressive functions
- Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing
- Progesterone Receptor Attenuates STAT1-Mediated Interferon Signaling in Breast Cancer
- Targeting Palbociclib-Resistant Estrogen Receptor-Positive Breast Cancer Cells via Oncolytic Virotherapy
- Increased expression of TRIP13 drives the tumorigenesis of bladder cancer in association with the EGFR signaling pathway
- Effect of Bazedoxifene and Conjugated Estrogen (Duavee®) on Breast Cancer Risk Biomarkers in High Risk Women: A Pilot Study
- The eIF2α kinase GCN2 modulates period and rhythmicity of the circadian clock by translational control of Atf4
- Molecular mechanisms underlying progesterone receptor action in breast cancer: insights into cell proliferation and stem cell regulation.
- Selective Progesterone Receptor Modulators in Early-Stage Breast Cancer: A Randomized, Placebo-Controlled Phase II Window-of-Opportunity Trial Using Telapristone Acetate
- MX2 is a novel regulator of cell cycle in melanoma cells
- Progesterone receptor promotes degradation of STAT2 to inhibit the interferon response in breast cancer
- Reciprocal fine-tuning of progesterone and prolactin-regulated gene expression in breast cancer cells
- KLF7 promotes pancreatic cancer growth and metastasis by up-regulating ISG expression and maintaining Golgi complex integrity
- Progesterone and Progesterone Receptors in Breast Cancer: Past, Present, Future
- Type I interferons and related pathways in cell senescence
- The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway
- Progesterone promotes immunomodulation and tumor development in the murine mammary gland
- UMP-CMP kinase 2 gene expression in macrophages is dependent on the IRF3-IFNAR signaling axis
- Bridging Radiotherapy to Immunotherapy: The IFN–JAK–STAT Axis
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