Increased glutamic acid decarboxylase expression in the hypothalamic suprachiasmatic nucleus in depression
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Summary
The finding of increased SCN GABA expression in female—but not in male-depression patients—may reflect the higher vulnerability for depression in women, and may significantly contribute to the disordered circadian rhythms in depression.
- Type
- article
- Published
- 2017-06-12
- Cited by
- 8
- References
- 53
- Access
- Open access
- OpenAlex
- https://openalex.org/W2626409159
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19971544
Keywords
Internal medicine, Endocrinology, Suprachiasmatic nucleus, Circadian rhythm, Glutamate decarboxylase
References
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- Mice Genetically Deficient in Vasopressin V1a and V1b Receptors Are Resistant to Jet Lag
- Desipramine does not alter plasma GABA in patients with major depression.
- Clinical and chronobiological effects of light therapy on nonseasonal affective disorders.
- The Intrinsic Optical Signal Evoked by Chiasm Stimulation in the Rat Suprachiasmatic Nuclei Exhibits GABAergic Day‐Night Variation
- Short circuiting the circadian system with a new generation of precision tools.
- Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland: Colocalization of MT1 with vasopressin, oxytocin, and corticotropin‐releasing hormone
- Suprachiasmatic nucleus organization
- GABA is the principal neurotransmitter of the circadian system.
- Sex differences in depression and anxiety disorders: potential biological determinants.
- Young Women With Major Depression Live on Higher Homeostatic Sleep Pressure Than Healthy Controls
- Bright white light therapy in depression: A critical review of the evidence.
- Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia.
Cited by
- Alterations in the steroid biosynthetic pathways in the human prefrontal cortex in mood disorders: A post‐mortem study
- The human hypothalamus in mood disorders: The HPA axis in the center
- Does Arginine Vasopressin Reflect HPA-axis Activation in Major Depressive Disorder?
- Glutamic Acid Decarboxylase Concentration Changes in Response to Stress and Altered Availability of Glutamic Acid in Rabbit (Oryctolagus cuniculus) Brain Limbic Structures
- Hypothalamic neuropeptides and neurocircuitries in Prader Willi syndrome
- Discovery of new genetic loci for male sexual orientation in Han population
- The HPA Axis as Target for Depression
- The photobiology of the human circadian clock
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- New functional aspects of the suprachiasmatic nucleus of the hypothalamus : International Symposium on New Functional Aspects of the Suprachiasmatic Nucleus of the Hypothalamus Osaka, Japan, October 1991