The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension
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Summary
It is shown here that chromatin loop size can be increased and that the duration with which cohesin embraces DNA determines the degree to which loops are enlarged, and that TADs reflect polyclonal collections of loops in the making.
- Type
- article
- Published
- 2017-05-04
- Cited by
- 704
- References
- 75
- Access
- Open access
- OpenAlex
- https://openalex.org/W2610160407
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:619650
Keywords
Biology, Cohesin, Chromatin, Extension (predicate logic), Cell biology
References
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- Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate
- WAPL-mediated removal of cohesin protects against segregation errors and aneuploidy.
- Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression.
- Biochemical reconstitution of topological DNA binding by the cohesin ring
- Wapl controls the dynamic association of cohesin with chromatin.
- The cohesin ring concatenates sister DNA molecules
Cited by
- The three-dimensional genome: regulating gene expression during pluripotency and development
- Dynamics of transcriptional enhancers and chromosome topology in gene regulation
- Scc2/Nipbl hops between chromosomal cohesin rings after loading
- Cohesin loss eliminates all loop domains, leading to links among superenhancers and downregulation of nearby genes
- Static and dynamic DNA loops form AP-1 bound activation hubs during macrophage development
- Connected Gene Communities Underlie Transcriptional Changes in Cornelia de Lange Syndrome
- Genome Organization Drives Chromosome Fragility
- Chromatin loop anchors are associated with genome instability in cancer and recombination hotspots in the germline
- Orientation-dependent Dxz4 contacts shape the 3D structure of the inactive X chromosome
- Brca2, Pds5 and Wapl differentially control cohesin chromosome association and function
- Single‐cell Hi‐C bridges microscopy and genome‐wide sequencing approaches to study 3D chromatin organization
- Towards quantitative analysis of gene regulation by enhancers.
- A mechanism of cohesin‐dependent loop extrusion organizes zygotic genome architecture
- CTCF, WAPL and PDS5 proteins control the formation of TADs and loops by cohesin
- GenomeDISCO: A concordance score for chromosome conformation capture experiments using random walks on contact map graphs
- Crossed wires: 3D genome misfolding in human disease
- Topological organization and dynamic regulation of human tRNA genes during macrophage differentiation
- The HoxD cluster is a dynamic and resilient TAD boundary controlling the segregation of antagonistic regulatory landscapes
- Two independent modes of chromatin organization revealed by cohesin removal
- Cohesin loss eliminates all loop domains
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