Effects of Age and Environment on Short-Term Homing and Function of Mouse Hematopoietic Stem Cells
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Summary
The proportion of purified old HSCs that were functional when assayed clonally in vitro (cobblestone area forming cell [CAFC] assay) declined approximately 2-fold compared to young H SCs, which suggests that the factors affecting homing are similar between individual young recipients, while the microenvironments of individual old recipients are variable in their relative ability to support homing of young and old Hscs.
- Type
- article
- Published
- 2010-11-19
- Cited by
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- OpenAlex
- https://openalex.org/W2589107051
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:90488116
Keywords
Homing (biology), Bone marrow, Stem cell, Haematopoiesis, Biology
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