The origins of developmental gene regulation
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Summary
The main hypothesis of this manuscript is that, developmental enhancers evolved from unicellular inducible promoters that diversified the expression of regulatory genes during metazoan evolution.
- Type
- article
- Published
- 2017-03-01
- Cited by
- 27
- References
- 154
- OpenAlex
- https://openalex.org/W2581702729
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25875826
Keywords
Promoter, Biology, Enhancer, Gene, Regulation of gene expression
References
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- Exploiting the yeast stress-activated signaling network to inform on stress biology and disease signaling
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- Establishment of regions of genomic activity during the Drosophila maternal to zygotic transition
- Transphyletic conservation of developmental regulatory state in animal evolution
- Integrative analysis of haplotype-resolved epigenomes across human tissues
- A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers
- Size and complexity among multicellular organisms
- Transcription elongation factors DSIF and NELF: promoter-proximal pausing and beyond.
- The unicellular ancestry of animal development.
- CTCF: An Architectural Protein Bridging Genome Topology and Function
Cited by
- The origin of Metazoa: a unicellular perspective
- How the evolution of multicellularity set the stage for cancer
- The degree of enhancer or promoter activity is reflected by the levels and directionality of eRNA transcription
- The evolutionary origins of cell type diversification and the role of intrinsically disordered proteins
- Evolution of the D. melanogaster chromatin landscape and its associated proteins
- Intrinsically Disordered Proteins Link Alternative Splicing and Post-translational Modifications to Complex Cell Signaling and Regulation.
- Transcriptional regulation by promoters with enhancer function
- Evolution of the Drosophila melanogaster Chromatin Landscape and Its Associated Proteins
- Inherency of Form and Function in Animal Development and Evolution
- Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer
- Cell differentiation: what have we learned in 50 years?
- Transcription factors and gene regulatory elements in the human malaria parasite. Plasmodium falciparum
- The origin of animal body plans: a view from fossil evidence and the regulatory genome
- In the Light of the Environment: Evolution Through Biogrammars Not Programmers
- Evolution of Regulated Transcription
- Identification and prediction of developmental enhancers in sea urchin embryos
- Epromoters function as a hub to recruit key transcription factors required for the inflammatory response
- When being flexible matters: Ecological underpinnings for the evolution of collective flexibility and task allocation
- The Curious Case of Multicellularity in the Volvocine Algae
- Accessibility and activity of transcriptional regulatory elements during sea urchin embryogenesis and differentiation
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