The role of transplanted visceral fat from the long-lived growth hormone receptor knockout mice on insulin signaling
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Summary
It is demonstrated that visceral fat transplant from GHRKO mice into normal mice enhanced insulin sensitivity and glucose tolerance and further confirms the differential physiological role played by visceral adipose tissue from GH receptor deficient mice, indicating that the increase of this fat depot can be associated with beneficial effects on insulin signaling and longevity.
- Type
- article
- Published
- 2017-01-18
- Cited by
- 36
- References
- 22
- Access
- Open access
- OpenAlex
- https://openalex.org/W2572146508
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3705916
Keywords
Endocrinology, Internal medicine, Adipose tissue, Insulin receptor, Insulin
References
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- Cross-Talk between PPARγ and Insulin Signaling and Modulation of Insulin Sensitivity
- PPARs in Calorie Restricted and Genetically Long-Lived Mice
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- Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
Cited by
- Demonstration of impaired neurovascular coupling responses in TG2576 mouse model of Alzheimer’s disease using functional laser speckle contrast imaging
- Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment
- Growth Hormone’s Effect on Adipose Tissue: Quality versus Quantity
- Connective tissue growth factor (CTGF) in age-related vascular pathologies
- Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer’s disease
- Dwarf Mice and Aging.
- Short-term weight loss reverses obesity-induced microvascular endothelial dysfunction
- Repeated Valsalva maneuvers promote symptomatic manifestations of cerebral microhemorrhages: implications for the pathogenesis of vascular cognitive impairment in older adults
- PACAP deficiency as a model of aging
- Growth Hormone Deficiency: Health and Longevity.
- Advances and challenges in geroscience research: An update
- Role of age-related alterations of the cerebral venous circulation in the pathogenesis of vascular cognitive impairment.
- Enteroendocrine Connections in Congenital Isolated GH Deficiency Due to a GHRH Receptor Gene Mutation.
- Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research
- GH "knockout" mice have increased subcutaneous adipose tissue with decreased fibrosis and enhanced insulin sensitivity.
- Effect of caloric restriction and rapamycin on ovarian aging in mice
- Potential Adverse Cardiovascular Effects of Treatment With Fluoxetine and Other Selective Serotonin Reuptake Inhibitors (SSRIs) in Patients With Geriatric Depression: Implications for Atherogenesis and Cerebromicrovascular Dysregulation
- Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects
- The enigmatic role of growth hormone in age-related diseases, cognition, and longevity
- Insulin signaling in the whole spectrum of GH deficiency
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