Extracellular vesicles in cancer: cell-to-cell mediators of metastasis
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Summary
Tumor-secreted extracellular vesicles are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments and orchestrate multiple systemic pathophysiological processes to support pre-metastatic niche formation and subsequent metastasis.
- Type
- review
- Published
- 2016-12-12
- Cited by
- 1,758
- References
- 149
- Access
- Open access
- OpenAlex
- https://openalex.org/W2567639438
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206527057
Keywords
Stromal cell, Metastasis, Microvesicles, Reprogramming, Extracellular vesicles
References
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- Emerging Roles of Exosomes in Normal and Pathological Conditions: New Insights for Diagnosis and Therapeutic Applications
- Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming
- Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
- Rab11 Promotes Docking and Fusion of Multivesicular Bodies in a Calcium‐Dependent Manner
- Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters
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- Exosomes in the tumor microenvironment as mediators of cancer therapy resistance
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- Exosomal microRNAs isolated from plasma of mesenteric veins linked to liver metastases in resected patients with colon cancer
- Cancer-associated circulating large extracellular vesicles in cholangiocarcinoma and hepatocellular carcinoma.
- Glycoconjugates from extracellular vesicles: Structures, functions and emerging potential as cancer biomarkers.
- The Molecular Connections between Lung and Pancreatic Cancer Metastases: are we not seeing the Forest for the Trees?
- Microfluidic based isolation of circulating tumor cells from whole blood for cancer diagnostics
- TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells
- Patient monitoring through liquid biopsies using circulating tumor DNA
- Aggressive rat prostate tumors reprogram the benign parts of the prostate and regional lymph nodes prior to metastasis
- Effect of the irradiation on Neuroblastoma-derived microvesicles: A physical and biological investigation
- Expression of CD38 in myeloma bone niche: A rational basis for the use of anti-CD38 immunotherapy to inhibit osteoclast formation
- Metalloproteinases in extracellular vesicles.
- Immunotherapeutic action of extracellular vesicles and effects of TLR signaling to immune dysfunction of SCI patients
- Extracellular Vesicles in Renal Pathophysiology
- Extracellular vesicles in the tumor microenvironment: Therapeutic resistance, clinical biomarkers, and targeting strategies
- Exosomes in diagnosis and therapy of prostate cancer
- Engineering the pre-metastatic niche
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