RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes
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Summary
It is discovered that the histone H2AK119 E3 ubiquitin ligase activity of Polycomb repressive complex 1 (PRC1) is defined by the composition of its catalytic subunits and is highly regulated by RYBP/YAF2-dependent stimulation, suggesting a localized form of epigenetic memory required for normal PcG chromatin domain function in gene regulation.
- Type
- article
- Published
- 2016-10-05
- Cited by
- 129
- References
- 118
- Access
- Open access
- OpenAlex
- https://openalex.org/W2529278390
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12024733
Keywords
PRC2, Polycomb-group proteins, Chromatin, Histone H3, Cell biology
References
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- A gene complex controlling segmentation in Drosophila
- Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes
- Role of the polycomb protein Eed in the propagation of repressive histone marks
Cited by
- Mechanisms Regulating PRC2 Recruitment and Enzymatic Activity.
- The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin
- Genome Regulation by Polycomb and Trithorax: 70 Years and Counting.
- Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function.
- Polycomb repressive complex 1 defines the nucleosome landscape but not accessibility at target genes
- Multiple roles of Ring 1 and YY1 binding protein in physiology and disease
- From Flies to Mice: The Emerging Role of Non-Canonical PRC1 Members in Mammalian Development
- FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment
- Genetic Mechanisms Regulating the Spatiotemporal Modulation of Proliferation Rate and Mode in Neural Progenitors and Daughter Cells during Embryonic CNS Development
- The polycomb group protein Yaf2 regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner
- PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading
- RYBP modulates stability and function of Ring1B through targeting UBE3A
- SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States.
- KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity
- Cell Fate and Developmental Regulation Dynamics by Polycomb Proteins and 3D Genome Architecture
- Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression
- Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing
- Topology and enzymatic properties of a canonical Polycomb repressive complex 1 isoform
- BCOR involvement in cancer
- PRC1 Catalytic Activity Is Central to Polycomb System Function
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