CCL22-specific T Cells: Modulating the immunosuppressive tumor microenvironment
Explore this paper's citation graph
Summary
Activating CCL22-specific T cells may directly target cancer cells and tumor-associated macrophages, thereby modulating Treg recruitment into the tumor environment and augmenting anticancer immunity.
- Type
- article
- Published
- 2016-09-30
- Cited by
- 65
- References
- 23
- Access
- Open access
- OpenAlex
- https://openalex.org/W2527534199
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30363970
Keywords
CCL22, Tumor microenvironment, Chemokine, Epitope, Cancer research
References
- The targeting of immunosuppressive mechanisms in hematological malignancies
- Clonal Deletion Prunes, but does not Eliminate Self-Specific αβ CD8+ T Lymphocytes
- Serum macrophage-derived chemokine/CCL22 levels are associated with glioma risk, CD4 T cell lymphopenia and survival time
- Cross-Presentation of HLA Class I Epitopes from Exogenous NY-ESO-1 Polypeptides by Nonprofessional APCs 1
- Immune Regulation by Self-Recognition: Novel Possibilities for Anticancer Immunotherapy.
- HLA-restricted CTL that are specific for the immune checkpoint ligand PD-L1 occur with high frequency in cancer patients.
- A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens.
- Innate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment
- High immunogenic potential of p53 mRNA-transfected dendritic cells in patients with primary breast cancer
- Design and use of conditional MHC class I ligands
- Regulatory T-cell inhibition versus depletion: the right choice in cancer immunotherapy
- HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation.
- Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival
- Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilege.
- Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4+Cd25+ Regulatory T Cells
- Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome.
- Early detection of tumor cells by innate immune cells leads to T(reg) recruitment through CCL22 production by tumor cells.
- Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors
- Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells.
- Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
Cited by
- Anti-regulatory T cells
- Host antitumor resistance improved by the macrophage polarization in a chimera model of patients with HCC
- A comparison of the molecular subtypes of triple-negative breast cancer among non-Asian and Taiwanese women
- Regulatory T cells as suppressors of anti-tumor immunity: Role of metabolism.
- Brain-derived neurotrophic factor (BDNF) -TrKB signaling modulates cancer-endothelial cells interaction and affects the outcomes of triple negative breast cancer
- The inhibitory checkpoint, PD-L2, is a target for effector T cells: Novel possibilities for immune therapy
- The Balance Players of the Adaptive Immune System.
- Immunoregulatory antigens-novel targets for cancer immunotherapy.
- The T-win® technology: immune-modulating vaccines
- Macrophage-derived CCL22 promotes an immunosuppressive tumor microenvironment via IL-8 in malignant pleural effusion.
- Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma
- WNT/β-Catenin Signaling Pathway Regulating T Cell-Inflammation in the Tumor Microenvironment
- Circ_0039569 promotes renal cell carcinoma growth and metastasis by regulating miR-34a-5p/CCL22.
- Arginase-1-based vaccination against the tumor microenvironment: the identification of an optimal T-cell epitope
- p65/miR‐23a/CCL22 axis regulated regulatory T cells recruitment in hepatitis B virus positive hepatocellular carcinoma
- The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses
- The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines
- Toxoplasma gondii GRA28 Is Required for Placenta-Specific Induction of the Regulatory Chemokine CCL22 in Human and Mouse
- Maximizing the potency of oxaliplatin coated nanoparticles with folic acid for modulating tumor progression in colorectal cancer.
- Linking Circulating Serum Proteins with Clinical Outcomes in Esophageal Adenocarcinoma—An Emerging Role for Chemokines
Related papers
- Changes in the Profiles of Chemokines Secreted by Endothelial Cells and Monocytes under Different Coculturing Conditions
- 27: Detection of HHV-6 in over a thousand samples: new types of infection revealed by the analysis of positive results
- A meta-analysis of chemokines in vitiligo: Recruiting immune cells towards melanocytes
- 28: Seroprevalences of human herpesviruses 6 and 7 in healthy persons in Slovenia
- Chemokine CXCL10 Modulates the Tumor Microenvironment of Fibrosis-Associated Hepatocellular Carcinoma
- Comprehensive analysis of serum cytokines/chemokines in febrile children with primary human herpes virus-6B infection.
- Cytokines in autoimmune lacrimal gland disease in MRL/MpJ mice.
- Increased mRNA Expression of CCL22 in Hepatocellular Carcinoma with Infiltration of FOXP3+ Regulatory T Cell: 339
- Interplay of Cytokines and Chemokines in the Pathogenesis of Systemic Lupus Erythematosus