The HPV16 E7 oncoprotein increases the expression of Oct3/4 and stemness-related genes and augments cell self-renewal.
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Summary
It is demonstrated that E7 is involved in cell self-renewal, suggesting that the HPV16 E7 oncoprotein upregulates Oct3/4, Sox2, Nanog and Fgf4 expression to maintain the self-Renewal capacity of cancer stem cells.
- Type
- article
- Published
- 2016-12-01
- Cited by
- 27
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W2525877122
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27314200
Keywords
Homeobox protein NANOG, SOX2, Biology, Downregulation and upregulation, Cell biology
References
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- The Differential Expression of OCT4 Isoforms in Cervical Carcinoma
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- OCT4 promotes tumorigenesis and inhibits apoptosis of cervical cancer cells by miR-125b/BAK1 pathway
- Differential expression of Oct4 in HPV-positive and HPV-negative cervical cancer cells is not regulated by DNA methyltransferase 3A
- Morusin inhibits human cervical cancer stem cell growth and migration through attenuation of NF-κB activity and apoptosis induction
Cited by
- Changing Stem Cell Dynamics during Papillomavirus Infection: Potential Roles for Cellular Plasticity in the Viral Lifecycle and Disease
- HPV-Induced Field Cancerisation: Transformation of Adult Tissue Stem Cell Into Cancer Stem Cell
- The Human Papillomavirus (HPV) E6 Oncoprotein Regulates CD40 Expression via the AT-Hook Transcription Factor AKNA
- TET1 promotes 5hmC-dependent stemness, and inhibits a 5hmC-independent epithelial-mesenchymal transition, in cervical precancerous lesions.
- Cervical cancer stem cell-associated genes: Prognostic implications in cervical cancer
- Conversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition
- Pterostilbene Suppresses both Cancer Cells and Cancer Stem-Like Cells in Cervical Cancer with Superior Bioavailability to Resveratrol
- Role of Oct3/4 in Cervical Cancer Tumorigenesis
- Human papillomavirus E7 binds Oct4 and regulates its activity in HPV-associated cervical cancers
- The HPV and p63 Status in Penile Cancer Are Linked with the Infiltration and Therapeutic Availability of Neutrophils
- The vaginal and fecal microbiota of a murine cervical carcinoma model under synergistic effect of 17β-Estradiol and E7 oncogene expression.
- The Vaginal and Fecal Microbiota associated to cervical cancer development in a mice model.
- Changes in Stem Cell Regulation and Epithelial Organisation during Carcinogenesis and Disease Progression in Gynaecological Malignancies
- Nanog, in Cooperation with AP1, Increases the Expression of E6/E7 Oncogenes from HPV Types 16/18
- Establishment of a Plasticity-Associated Risk Model Based on a SOX2- and SOX9-Related Gene Set in Head and Neck Squamous Cell Carcinoma
- IDKK1 inhibits canonical Wnt signaling in human papillomavirus-positive penile cancer cells
- Cancer Stem Cells: An Ever-Hiding Foe.
- The expression of Oct3/4A mRNA and not its isoforms is upregulated by the HPV16 E7 oncoprotein
- Antitumor activity of galaxamide involved in cell apoptosis and stemness by inhibiting Wnt/β‐catenin pathway in cervical cancer
- Application of mass cytometry in multiparametric characterization of precancerous cervical lesions
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