Alzheimer's disease: Attack on amyloid-β protein
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Summary
Treatment with aducanumab reduced brain Aβ plaques, an action accompanied by a dose-dependent slowing of clinical decline, which supports further development of aducAnumab as an Aβ-removing therapy.
- Type
- letter
- Published
- 2016-08-31
- Cited by
- 47
- References
- 7
- Access
- Open access
- OpenAlex
- https://openalex.org/W2511203602
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1218590
Keywords
Amyloid (mycology), Disease, Monoclonal antibody, Cognitive decline, Medicine
References
- Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
- Associations Between Biomarkers and Age in the Presenilin 1 E280A Autosomal Dominant Alzheimer Disease Kindred A Cross-sectional Study
- Developing Therapeutic Antibodies for Neurodegenerative Disease
- Amyloid Related Imaging Abnormalities (ARIA) in Amyloid Modifying Therapeutic Trials: Recommendations from the Alzheimer’s Association Research Roundtable Workgroup
- CAP—advancing the evaluation of preclinical Alzheimer disease treatments
- The amyloid hypothesis of Alzheimer's disease at 25 years
- The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
Cited by
- Current opinion in Alzheimer's disease therapy by nanotechnology-based approaches
- Hyperbaric Oxygen Prevents Cognitive Impairments in Mice Induced by d-Galactose by Improving Cholinergic and Anti-apoptotic Functions
- APP as a Protective Factor in Acute Neuronal Insults
- UB-311, a novel UBITh® amyloid β peptide vaccine for mild Alzheimer's disease
- Spatial regulation of brain derived neurotrophic factor (BDNF) expression in sensory neurons by microRNA-206
- D-4F decreases the expression of Aβ protein through up-regulating long non coding RNA sirt1-as in SAMP8 mice
- Chrysophanol Suppressed Glutamate-Induced Hippocampal Neuronal Cell Death via Regulation of Dynamin-Related Protein 1-Dependent Mitochondrial Fission
- Parsing Disease-relevant Protein Modifications from Epiphenomena: Perspective on the Structural Basis of SOD1-Mediated ALS
- Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases.
- Blocking beta 2-adrenergic receptor inhibits dendrite ramification in a mouse model of Alzheimer's disease
- A&bgr;1‐42 induces cell damage via RAGE‐dependent endoplasmic reticulum stress in bEnd.3 cells
- Light-triggered dissociation of self-assembled β-amyloid aggregates into small, nontoxic fragments by ruthenium (II) complex.
- Effect of solvent selectivity on crystallization-driven fibril growth kinetics of diblock copolymers
- The physics of polymer chain-folding
- Opening the debate on deep brain stimulation for Alzheimer disease – a critical evaluation of rationale, shortcomings, and ethical justification
- Ultrasensitive photoelectrochemical immunosensor for the detection of amyloid β-protein based on SnO2/SnS2/Ag2S nanocomposites.
- Anti-diabetic vanadyl complexes reduced Alzheimer’s disease pathology independent of amyloid plaque deposition
- TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer’s disease
- Converging pathways in neurodegeneration, from genetics to mechanisms
- Defragmentation of lysozyme derived Amyloid β fibril using Biocompatible Magnetic fluid
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