Physiology of ionophore transport of potassium and sodium ions across cell membranes: valinomycin and 18-crown-6 ether
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Summary
Results from this study show that it is possible to design molecular structures to enhance the ability of crown ethers to selectively transport alkali metal ions across lipid membranes.
- Type
- article
- Published
- 2016-08-16
- Cited by
- 22
- References
- 61
- Access
- Open access
- OpenAlex
- https://openalex.org/W2507718813
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26640449
Keywords
Ionophore, Valinomycin, Chemistry, Membrane, Crown ether
References
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- Selective cytotoxic activity of valinomycin against HT-29 Human colon carcinoma cells via down-regulation of GRP78.
- The ion selectivity of nonelectrogenic ionophores measured on a bilayer lipid membrane: nigericin, monensin, A23187 and lasalocid A.
- A method to predict blood-brain barrier permeability of drug-like compounds using molecular dynamics simulations.
- The rate constants of valinomycin-mediated ion transport through thin lipid membranes.
- Crystal structure of valinomycin-sodium picrate. Anion effects on valinomycin-cation complexes
- Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions.
- Stability of sodium and potassium complexes of valinomycin
- Variability of crown ether toxicity
- Selective transport of Li+ across lipid bilayer membranes mediated by an ionophore of novel design (ETH1644)
- Effect of Membrane Tension on the Electric Field and Dipole Potential of Lipid Bilayer Membrane
- Statins in therapy: understanding their hydrophilicity, lipophilicity, binding to 3-hydroxy-3-methylglutaryl-CoA reductase, ability to cross the blood brain barrier and metabolic stability based on electrostatic molecular orbital studies.
- Potassium permeability of single compartment liposomes with and without valinomycin.
- Experimental and theoretical study of the coordination of 1,2,4-triazolato, tetrazolato, and pentazolato ligands to the [K(18-crown-6)]+ fragment.
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- The extravascular penetration of tirapazamine into tumours: a predictive model of the transport and efficacy of hypoxia specific cytotoxic analogues and the potential use of cucurbiturils to facilitate delivery
- The role of free radicals in the effectiveness of anti-cancer chemotherapy in hypoxic ovarian cells and tumours
- The binding of ligands to thrombin, trypsin and avidin: validation of a structure activity model
- Determination of Carbonic Acid Species Using Carbonate- and Novel Bicarbonate-Selective Electrodes
- Biodegradation of antibiotics: the new resistance determinants - part I.
- Predicting hydrophobic alkyl-alkyl and perfluoroalkyl-perfluoroalkyl van der Waals dispersion interactions and their potential involvement in protein folding and the binding of drugs in hydrophobic pockets
- Drug discovery model using molecular orbital computations: tyrosine kinase inhibitors
- Toxicology of platinum anticancer drugs: oxidative stress and antioxidant effect of stable free radical Pt-nitroxides
- Comparison of choline blood brain barrier and neuronal transport and anticholinesterase inhibitory properties of potential cationic Alzheimers disease drugs
- Discovery of Novel Cyclic Ethers with Synergistic Antiplasmodial Activity in Combination with Valinomycin
- Biodegradation of antibiotics: the new resistance determinants - part II.
- Na,K‐ATPase: A murzyme facilitating thermodynamic equilibriums at the membrane‐interface
- Tandem LC-MS Identification of Antitubercular Compounds in Zones of Growth Inhibition Produced by South African Filamentous Actinobacteria
- Repurposing Polyether Ionophores as a New-Class of Anti-SARS-Cov-2 Agents as Adjunct Therapy
- Spectroscopic, Spectrometric and Computational Studies of New Lasalocid Derivatives and Their Complexes with Selected Metal Cations
- High sensitivity mercury ion detection via thermal shock and quench with molecular sieve-functionalized FETs
- Novel Crown Ether-Functionalized Fusidic Acid Butyl Ester: Synthesis, Biological Evaluation, In Silico ADMET, and Molecular Docking Studies
- Is the beta-subunit of Na,K-ATPase (NKA) a murzyme? Explaining the modulations by lithium ion, trans-dermal peptide, cardiotonic steroids, volatile anesthetics, arginine, dinitrophenol, and diverse antioxidants in NKA-aided neuro-musculo-electrophysiology
- Free radical anticancer drugs and oxidative stress: ORAC and CellROX-colorectal cancer cells by quantum chemical determinations
- A drug based model to predict enhanced transdermal and blood brain barrier drug deliverability using ultrasonic methods
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