Rationale for immune-based therapies in Merkel polyomavirus-positive and -negative Merkel cell carcinomas.
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Summary
In particular, agents blocking the PD-1 axis have yielded strikingly high response rates in MCC as compared with other solid tumors, highlighting the potential for immune-mediated treatment of this disease.
- Type
- review
- Published
- 2016-07-06
- Cited by
- 22
- References
- 142
- Access
- Open access
- OpenAlex
- https://openalex.org/W2463638303
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4230244
Keywords
Merkel cell polyomavirus, Merkel cell carcinoma, Merkel cell, Immune system, Polyomavirus Infections
References
- Temporary regression of Merkel cell carcinoma metastases after cessation of cyclosporine.
- Type I and II IFNs inhibit Merkel cell carcinoma via modulation of the Merkel cell polyomavirus T antigens.
- Merkel polyomavirus-specific T cells fluctuate with Merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers
- Perioperative treatment with the new synthetic TLR-4 agonist GLA-SE reduces cancer metastasis without adverse effects
- CTLA-4 and PD-1 Pathways
- A case of complete spontaneous regression of extremely advanced Merkel cell carcinoma
- Tricking the balance: NK cells in anti-cancer immunity.
- Merkel cell carcinoma: emerging biology, current approaches, and future directions.
- Downregulation of Toll-Like Receptor 9 Expression by Beta Human Papillomavirus 38 and Implications for Cell Cycle Control
- Retargeting of natural killer-cell cytolytic activity to ErbB2-expressing cancer cells results in efficient and selective tumor cell destruction.
- Suppression, subversion and escape: the role of regulatory T cells in cancer progression
- B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
- Targeting the tumor microenvironment to enhance antitumor immune responses
- Antibody-dependent cellular cytotoxicity (ADCC) activity of a novel anti-PD-L1 antibody avelumab (MSB0010718C) on human tumor cells
- Serine 220 phosphorylation of the Merkel cell polyomavirus large T antigen crucially supports growth of Merkel cell carcinoma cells
- Molecular and cellular insights into T cell exhaustion
- The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma
- Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies.
- Nitric oxide-producing myeloid-derived suppressor cells inhibit vascular E- selectin expression in human squamous cell carcinomas
- An intact retinoblastoma protein‐binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cells
Cited by
- Merkel Cell Carcinoma: An Unusually Immunogenic Cancer Proves Ripe for Immune Therapy.
- Preclinical evaluation of NF-κB-triggered dendritic cells expressing the viral oncogenic driver of Merkel cell carcinoma for therapeutic vaccination
- Advances in Merkel cell carcinoma from a pathologist's perspective.
- Merkel cell carcinomas infiltrated with CD33+ myeloid cells and CD8+ T cells are associated with improved outcome
- Avelumab: a new standard for treating metastatic Merkel cell carcinoma
- Radiotherapy for inoperable Merkel cell carcinoma: a systematic review and pooled analysis
- In-field and abscopal response after short-course radiation therapy in patients with metastatic Merkel cell carcinoma progressing on PD-1 checkpoint blockade: a case series
- Merkel Cell Carcinoma: Updates on Pathogenesis, Diagnosis, and Management
- Intratumoral G100, a TLR4 agonist, induces anti-tumor immune responses and tumor regression in patients with Merkel cell carcinoma
- Treatment of Advanced Merkel Cell Carcinoma: Current Therapeutic Options and Novel Immunotherapy Approaches
- Merkel cell carcinoma of the eyelid: A review.
- Foci of Programmed Cell Death-Ligand 1 (PD-L1)-positive Tumor Areas With Tumor-infiltrating Leukocytes (TILs) Evocative of a PD-1/PD-L1-related Adaptive Immune Resistance are Frequent in Merkel Cell Carcinoma
- Updates on Merkel Cell Carcinoma.
- Beta Human Papillomavirus and Merkel Cell Polyomavirus in Skin Neoplasms
- Exámenes virológicos útiles en dermatología
- Defining Novel DNA Virus-Tumor Associations and Genomic Correlates using Prospective Clinical Tumor/Normal Matched Sequencing Data.
- Merkelcelcarcinoom
- First-line Immunotherapy for Metastatic Merkel Cell Carcinoma
- Examens virologiques utiles en dermatologie
- The role of pioneering transcription factors, chromatin accessibility and epigenetic reprogramming in oncogenic viruses
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