A Pharmacokinetic Approach to Postoperative Pain: Continuous Infusion of Pethidine
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Summary
Control continuous intravenous infusion of pethidine produced stable blood concentrations and provided excellent pain control and significant blood concentrations of the metabolite norpethidine were found although clinically no toxic effects were observed.
- Type
- article
- Published
- 1979-02-01
- Cited by
- 89
- References
- 20
- Access
- Open access
- OpenAlex
- https://openalex.org/W2410359872
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:38907223
Keywords
Pethidine, Medicine, Anesthesia, Pharmacokinetics, Regimen
References
- Application of Nonparametric Procedure for Bioassay Data to the Evaluation of Analgesics in Man
- Interactive simulator for pharmacokinetics of repetitive drug dosing.
- A quantitative gas-liquid chromatographic method for the determination of pethidine and its metabolites, norpethidine and pethidine N-oxide in human biological fluids
- The Bioavailability of Meperidine
- Meperidine and other basic drugs: general method for their determination in plasma.
- Comparisons of the Analgesic Effects of Oral and Intramuscular Oxymorphone and of Intramuscular Oxymorphone and Morphine in Patients with Cancer
- Pethidine revisited: plasma concentrations and effects after intramuscular injection.
- A double-blind comparison of morphine and buprenorphine in the prevention of pain after operation.
- The Clinical Pharmacology of Meperidine—Comparison of Routes of Administration
- REVERSIBLE, TITRATED DEEP SEDATION FOR MAJOR OFFICE SURGERY
- A comparison of buprenorphine and pethidine for immediate postoperative pain relief by the i.v. route.
- Nonparametric statistics for the behavioral sciences
- THE CLINICAL EVALUATION OF MORPHINE AND ITS SUBSTITUTES AS ANALGESICS.
- Ed50 Values for Thiopentone, Methohexital Propanidid and Alfathesin: A Clinical Experiment
- The effect of N-demethylation on certain pharmacologic actions of morphine, codeine, and meperidine in the mouse.
- Postoperative demand analgesia.
- Postoperative pain.
- THE EFFECTOF AGEING ON PLASMA PETHIDINECONCENTRATION
Cited by
- Serum concentrations of meperidine in patients with sickle cell crisis.
- Meperidine infusion for postoperative analgesia in grossly obese patients
- Role of dexmedetomidine in early extubation of the intensive care unit patients
- Postoperative On-Demand Analgesie mit Pentazocin (Fortral)
- A Double-Blind Randomised Trial Comparing Postoperative Analgesia after Perioperative Loading doses of Methadone or Morphine
- Pain management and sedation in the pediatric intensive care unit.
- Transdermal Fentanyl: Pharmacokinetics and Preliminary Clinical Evaluation
- Sedation and Analgesia for Children in the Pediatric Intensive Care Unit
- Rate of formation of norpethidine from pethidine.
- Analgesic, hemodynamic, and respiratory effects induced by caudal epidural administration of meperidine hydrochloride in mares.
- Postoperative Analgesia Following Caesarean Section: Intravenous Patient Controlled Analgesia versus Conventional Continuous Infusion
- Effect of phenytoin on meperidine clearance and normeperidine formation
- Pharmacokinetics of meperidine in spinal anaesthesia.
- A comparative study of the efficacy and pharmacokinetics of oral methadone and morphine in the treatment of severe pain in patients with cancer.
- Newer Methods of Delivery of Opiates for Relief of Pain
- The efficacy of transdermal fentanyl in the treatment of postoperative pain: a double‐blind comparison of fentanyl and placebo systems
- New narcotic agonists and antagonists in anaesthesia
- Observational study to assess the effectiveness of postoperative pain management of patients undergoing elective cesarean section
- Efficacy of Nonsteroidal Anti-Inflammatory Drugs in the Management of Postoperative Pain
- A controlled study of a serotonin reuptake blocker, zimelidine, in the treatment of chronic pain
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