Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases.
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Summary
This review article provides an up-to-date overview of the structures and functions of all putative Rab-GEFs in mammals, with a special focus on their substrate Rabs, interacting proteins, associations with genetic diseases, and intracellular localizations.
- Type
- review
- Published
- 2016-05-27
- Cited by
- 64
- References
- 193
- Access
- Open access
- OpenAlex
- https://openalex.org/W2406985299
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23763141
Keywords
Rab, Guanine nucleotide exchange factor, GTPase, Cell biology, Nucleotide
References
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- Rabaptin5 is recruited to endosomes by Rab4 and Rabex5 to regulate endosome maturation
- A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1
- The building BLOC(k)s of lysosomes and related organelles.
- Longin and GAF Domains: Structural Evolution and Adaptation to the Subcellular Trafficking Machinery
- Crystal structure of the Sec4p·Sec2p complex in the nucleotide exchanging intermediate state
- Warburg Micro syndrome is caused by RAB18 deficiency or dysregulation
- REI-1 Is a Guanine Nucleotide Exchange Factor Regulating RAB-11 Localization and Function in C. elegans Embryos.
- TOR Complexes and the Maintenance of Cellular Homeostasis.
- The RAS Effector RIN1 Modulates the Formation of Aversive Memories
- Rab9A is required for delivery of cargo from recycling endosomes to melanosomes
- Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1
- Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3)*
- Structure of Rab11–FIP3–Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11
- Imaging of Rab5 activity identifies essential regulators for phagosome maturation
- A Rab8 Guanine Nucleotide Exchange Factor-Effector Interaction Network Regulates Primary Ciliogenesis*
Cited by
- RAB GEFs exchange GTP for GDP on RABs
- The small GTPase, Rab27, and its effectors and regulators participate in granule exocytosis by parotid acinar cells
- Look who’s talking—the crosstalk between oxidative stress and autophagy supports exosomal-dependent release of HCV particles
- Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1–Ccz1
- Molecular control of Rab activity by GEFs, GAPs and GDI
- TBC1D12 is a novel Rab11-binding protein that modulates neurite outgrowth of PC12 cells
- Rab32 subfamily small GTPases: pleiotropic Rabs in endosomal trafficking.
- Into the linker's DENN: A tyrosine's control of autophagy
- Autophagy as a double-edged sword in pulmonary epithelial injury: a review and perspective.
- Protein Interactions in the Last Steps of the Endosomal Degradative Pathway
- Plant exosomes: using an unconventional exit to prevent pathogen entry?
- The two TRAPP complexes of metazoans have distinct roles and act on different Rab GTPases
- RAB39A: a Rab small GTPase with a prominent role in cancer stemness.
- Insights into aluminum-tolerance pathways in Stylosanthes as revealed by RNA-Seq analysis
- Integration of two RAB5 groups during endosomal transport in plants
- Rab GTPases in Osteoclastic Endomembrane Systems
- FgSec2A, a guanine nucleotide exchange factor of FgRab8, is important for polarized growth, pathogenicity and deoxynivalenol production in Fusarium graminearum
- Rab17 regulates apical delivery of hepatic transcytotic vesicles
- This Is the End: Regulation of Rab7 Nucleotide Binding in Endolysosomal Trafficking and Autophagy
- Grab recruitment by Rab27A-Rabphilin3a triggers Rab3A activation in human sperm exocytosis.
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