Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans
Explore this paper's citation graph
Summary
It is suggested that the Neandertal-introgressed haplotype likely reintroduced an ancestral splice variant of OAS1 encoding a more active protein, suggesting that adaptive introgression occurred as a means to resurrect adaptive variation that had been lost outside Africa.
- Type
- preprint
- Published
- 2016-09-12
- Cited by
- 134
- References
- 67
- Access
- Open access
- OpenAlex
- https://openalex.org/W2346191908
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8778117
Keywords
Introgression, Biology, Haplotype, Locus (genetics), Genetics
References
- Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape
- Ancient human genomes suggest three ancestral populations for present-day Europeans
- Evidence for archaic adaptive introgression in humans
- Subcortical barrelette-like and barreloid-like structures in the prosimian galago (Otolemur garnetti)
- Single nucleotide polymorphism at exon 7 splice acceptor site of OAS1 gene determines response of hepatitis C virus patients to interferon therapy
- Systemic infection of mice by wild-type but not Spv- Salmonella typhimurium is enhanced by neutralization of gamma interferon and tumor necrosis factor alpha
- Role of gamma interferon and tumor necrosis factor alpha in resistance to Salmonella typhimurium infection
- Preserving immune diversity through ancient inheritance and admixture.
- Demographic history and rare allele sharing among human populations
- Statistical significance for genomewide studies
- Resurrecting Surviving Neandertal Lineages from Modern Human Genomes
- The genome sequence of a 45,000-year-old modern human from western Siberia
- Host Genetic Risk Factors for West Nile Virus Infection and Disease Progression
- The ribonuclease l‐dependent antiviral roles of human 2′,5′‐oligoadenylate synthetase family members against hepatitis C virus
- Determination of the DNA-binding kinetics of three related but heteroimmune bacteriophage repressors using EMSA and SPR analysis
- Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes
- Molecular Editing of Cellular Responses by the High Affinity Receptor for IgE
- Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows
- A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies
- Genetic history of an archaic hominin group from Denisova Cave in Siberia
Cited by
- Evidence that RNA viruses drove of adaptive introgression between Neanderthals and modern humans
- An evolutionary medicine perspective on Neandertal extinction
- Living in an adaptive world: Genomic dissection of the genus Homo and its immune response
- RNA viruses drove adaptive introgressions between Neanderthals and modern humans
- Functional implications of Neandertal introgression in modern humans
- Human Genomics of Mycobacterium tuberculosis Infection and Disease
- Harnessing ancient genomes to study the history of human adaptation
- The contribution of admixture to primate evolution.
- The Contribution of Neanderthals to Phenotypic Variation in Modern Humans
- Model-based detection and analysis of introgressed Neanderthal ancestry in modern humans
- Detection and Classification of Hard and Soft Sweeps from Unphased Genotypes by Multilocus Genotype Identity
- Neanderthal language revisited: not only us
- Something old, something borrowed: admixture and adaptation in human evolution.
- Human Stem Cell Resources Are an Inroad to Neandertal DNA Functions
- Recurrent loss-of-function mutations reveal costs to OAS1 antiviral activity in primates
- Molecular Mechanisms for the Adaptive Switching Between the OAS/RNase L and OASL/RIG-I Pathways in Birds and Mammals
- Evolutionary and Medical Consequences of Archaic Introgression into Modern Human Genomes
- Genetic and evolutionary determinants of human population variation in immune responses.
- The genomic impact of historical hybridization with massive mitochondrial DNA introgression
- [A biological anthropology of the disappearance of the Neandertal Man: recent data].
Related papers
- The fractional coalescent
- An instantaneous coalescent method insensitive to population structure.
- Impact of Ghost Introgression on Coalescent-based Species Tree Inference and Estimation of Divergence Time
- Sampling among haplotype resolutions in a coalescent‐based genealogy sampler
- A Bayesian implementation of the multispecies coalescent model with introgression for comparative genomic analysis
- Widespread Adaptive Introgression of Major Histocompatibility Complex Genes across Vertebrate Hybrid Zones
- Repeated Adaptive Introgression at a Gene under Multiallelic Balancing Selection