Brain Region-specific Organoids using Mini-bioreactors for Modeling ZIKV Exposure
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Summary
A miniaturized spinning bioreactor (SpinΩ) is developed to generate forebrain-specific organoids from human iPSCs that recapitulate key features of human cortical development, including progenitor zone organization, neurogenesis, gene expression, and notably, a distinct human-specific outer radial glia cell layer.
- Type
- article
- Published
- 2016-04-22
- Cited by
- 1,933
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W2341041396
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26550483
Keywords
Biology, Organoid, Computational biology, Mammalian brain, Virology
References
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- KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas
- FOXG1-dependent dysregulation of GABA/glutamate neuron differentiation in autism spectrum disorders
- Sex-specific epigenetic disruption and behavioral changes following low-dose in utero bisphenol A exposure
- The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons.
- Dorsal radial glial cells have the potential to generate cortical interneurons in human, but not in mouse brain
- Development and Evolution of the Human Neocortex
- Cerebral organoids model human brain development and microcephaly
- The murine Otp homeobox gene plays an essential role in the specification of neuronal cell lineages in the developing hypothalamus.
- Prospects for use of microgravity‐based bioreactors to study three‐dimensional host—tumor interactions in human neoplasia
- Molecular Pathways Controlling Development of Thalamus and Hypothalamus: From Neural Specification to Circuit Formation
- Interplay between DISC1 and GABA Signaling Regulates Neurogenesis in Mice and Risk for Schizophrenia
- Organogenesis in a dish: Modeling development and disease using organoid technologies
- Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell–derived neocortex
- Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells.
- Genetic Characterization of Zika Virus Strains: Geographic Expansion of the Asian Lineage
- Origins of Cortical GABAergic Neurons in the Cynomolgus Monkey
Cited by
- Western Zika Virus in Human Fetal Neural Progenitors Persists Long Term with Partial Cytopathic and Limited Immunogenic Effects
- Human astrocytes are distinct contributors to the complexity of synaptic function
- Neuroimaging findings of Zika virus infection: a review article
- Visualization of migration of human cortical neurons generated from induced pluripotent stem cells.
- Self-organized cerebral organoids with human specific features predict effective drugs to combat Zika virus infection
- Applications of human brain organoids to clinical problems
- Compartmentalized devices as tools for investigation of human brain network dynamics
- Brain organoids and the study of neurodevelopment
- Generation and Fusion of Human Cortical and Medial Ganglionic Eminence Brain Organoids
- Zika virus: An update on epidemiology, pathology, molecular biology, and animal model
- Chloroquine inhibits Zika Virus infection in different cellular models
- The Brazilian Zika virus strain causes birth defects in experimental models
- Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice.
- Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice
- Combined proteome and transcriptome analyses reveal that Zika virus circulating in Brazil alters cell cycle and neurogenic programmes in human neurospheres
- Techniques: Spinning organoids shed light on Zika
- Stem Cell Models of Human Brain Development.
- Neural stem cells attacked by Zika virus
- Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development
- How iPS cells changed the world
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