Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome.
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Summary
In patients with acute lung injury and ARDS who receive mechanical ventilation with a tidal-volume goal of 6 ml per kilogram of predicted body weight and an end-inspiratory plateau-pressure limit of 30 cm of water, clinical outcomes are similar whether lower or higher PEEP levels are used.
- Type
- article
- Published
- 2009-10-08
- Cited by
- 2,285
- References
- 42
- OpenAlex
- https://openalex.org/W2333411966
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25709565
Keywords
Medicine, ARDS, Positive end-expiratory pressure, Mechanical ventilation, Anesthesia
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- PEEP and ventricular function
- Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS.
- Statistical Data Analysis in the Computer Age
- Adverse effects of large tidal volume and low PEEP in canine acid aspiration.
- Elevated pulmonary edema fluid concentrations of soluble intercellular adhesion molecule-1 in patients with acute lung injury: biological and clinical significance.
- Lung-protective ventilation strategies in acute lung injury
- The Statistical Analysis of Failure Time Data
- Histopathologic pulmonary changes from mechanical ventilation at high peak airway pressures.
Cited by
- Severe respiratory failure: Advanced treatment options
- Mechanical ventilation affects inflammatory mediators in patients undergoing cardiopulmonary bypass for cardiac surgery: a randomized clinical trial.
- Clinical year in review IV: asthma, chronic obstructive pulmonary disease, exercise and rehabilitation, and critical care medicine.
- The left heart can only be as good as the right heart: determinants of function and dysfunction of the right ventricle.
- Six-month survival of patients with acute lung injury: Prospective cohort study*
- Treatment of acute lung injury: clinical and experimental studies.
- The oxygenation ratio during mechanical ventilation in children: the role of tidal volume and positive end-expiratory pressure.
- Impact of acute hypercapnia and augmented positive end-expiratory pressure on right ventricle function in severe acute respiratory distress syndrome
- Peer reviewing critical care: a pragmatic approach to quality management
- On coenrollment in clinical resuscitation studies: review and experience from randomized trials.
- Short-Term Mortality Prediction for Acute Lung Injury Patients: External Validation of the ARDSNet Prediction Model
- Lung regional metabolic activity and gas volume changes induced by tidal ventilation in patients with acute lung injury.
- H1N1 Influenza: Critical Care Aspects
- Tidal ventilation distribution during pressure‐controlled ventilation and pressure support ventilation in post‐cardiac surgery patients
- Pulmonary Pressure-volume Curves of Elastase-treated and Control Rats
- Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial
- Severe refractory hypoxaemia in H1N1 (2009) intensive care patients: initial experience in an Asian regional hospital.
- Management of severe sepsis: role of "bundles".
- Low Tidal Volume Strategy: What Else?
- Post-pandemic acute respiratory distress syndrome: A New Global Definition with extension to lower-resource regions.
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