The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.
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Summary
Blockade of aldosterone receptors by spironolactone, in addition to standard therapy, substantially reduces the risk of both morbidity and death among patients with severe heart failure.
- Type
- article
- Published
- 1999-09-02
- Cited by
- 8,224
- References
- 41
- Access
- Open access
- OpenAlex
- https://openalex.org/W2323458614
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45060523
Keywords
Spironolactone, Medicine, Heart failure, Digoxin, Internal medicine
References
- Results of the ATLAS study. High or low doses of ACE inhibitors for heart failure?
- Angiotensin-converting enzyme inhibitor and spironolactone combination therapy. New objectives in congestive heart failure treatment.
- Thapsigargin-induced increase in cytoplasmic Ca2+ concentration and aldosterone production in rat adrenal glomerulosa cells: interaction with potassium and angiotensin-II.
- Rise in plasma concentration of aldosterone during long-term angiotensin II suppression.
- Pathological Hypertrophy and Cardiac Interstitium: Fibrosis and Renin‐Angiotensin‐Aldosterone System
- Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion.
- Discrete sequential boundaries for clinical trials
- Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group.
- Effects of enalapril on mortality in severe congestive heart failure: results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS).
- Aldosterone escape during angiotensin-converting enzyme inhibitor therapy in chronic heart failure.
- Interactions between ouabain, atrial natriuretic peptide, angiotensin-II and potassium: effects on rat zona glomerulosa aldosterone production.
- Effects of adding spironolactone to an angiotensin-converting enzyme inhibitor in chronic congestive heart failure secondary to coronary artery disease.
- A multiple testing procedure for clinical trials.
- Relation of the Renin‐Angiotensin-Aldosterone System to Clinical State in Congestive Heart Failure
- Efficacy and tolerance of spironolactone in essential hypertension.
- Antihypertensive Therapy with MK 4211: Angiotensin II‐Renin Relationships to Evaluate Efficacy of Converting Enzyme Blockade
- Successes and failures of current treatment of heart failure.
- Aldosterone and antialdosterone therapy in congestive heart failure.
- Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients.
- Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro.
Cited by
- N-terminal pro-B-type natriuretic peptide-guided treatment for chronic heart failure: results from the BATTLESCARRED (NT-proBNP-Assisted Treatment To Lessen Serial Cardiac Readmissions and Death) trial.
- Cost Effectiveness of Eplerenone in Patients with Heart Failure after Acute Myocardial Infarction Who were Taking Both ACE Inhibitors and β-Blockers
- Effects of heart failure management programmes
- Race/Ethnicity: Is it an Outcome Predictor in Patients with Heart Failure?
- [The German National Disease Management Guideline "Chronic Heart Failure"].
- 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension
- Electrogram characteristics in postinfarction ventricular tachycardia: effect of infarct age.
- Aldosteron und Hypertonie
- Plasma aldosterone concentrations are not related to the degree of angiotensin-converting enzyme inhibition in essential hypertensive patients.
- Nonsustained ventricular tachycardia.
- Reversal of Heart Failure Remodeling in Women
- Surgical alternatives to mechanical support
- Chagas' Heart Disease
- Pathogenesis and management of sodium and water retention in cardiac failure and cirrhosis.
- Reply: To PMID 24846806.
- The Kidney in Congestive Heart Failure: Renal Adverse Event Rate of Treatment
- Medical therapy or coronary artery bypass graft surgery for chronic stable angina: an update using decision analysis.
- The oxidative stress hypothesis of congestive heart failure: radical thoughts.
- Dietary prevention of sudden cardiac death.
- Torasemide in chronic heart failure: results of the TORIC study
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