Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease.
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Summary
In this trial among healthy men, 12 years of supplementation with beta carotene produced neither benefit nor harm in terms of the incidence of malignant neoplasms, cardiovascular disease, or death from all causes.
- Type
- article
- Published
- 1996-05-02
- Cited by
- 2,395
- References
- 31
- Access
- Open access
- OpenAlex
- https://openalex.org/W2315403385
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17357275
Keywords
Medicine, Placebo, Incidence (geometry), Internal medicine, Cancer
References
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- Cancer: Principles and Practice of Oncology
- Dietary factors in cancer of the lower urinary tract
- Dietary Antioxidants and Cardiovascular Disease
- Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population.
- A clinical trial of beta carotene to prevent basal-cell and squamous-cell cancers of the skin. The Skin Cancer Prevention Study Group.
- Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease.
- Book ReviewAmbulatory Pediatric Care
- Vitamin E consumption and the risk of coronary heart disease in men.
- Serum beta-carotene, vitamins A and E, selenium, and the risk of lung cancer.
- Biochemical markers of compliance in the Physicians' Health Study.
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- Meta-analysis Spurious precision? Meta-analysis of observational studies
- Dietary change as a strategy for preventing cancer
- Dietary antioxidants and risk of myocardial infarction in the elderly: the Rotterdam Study.
- Oxidative DNA damage in vivo: relationship to age, plasma antioxidants, drug metabolism, glutathione-S-transferase activity and urinary creatinine excretion.
- Vitamin E and vascular homeostasis: implications for atherosclerosis
- Impact of nondigestible carbohydrates on serum lipoproteins and risk for cardiovascular disease.
- Uric acid and serum antioxidant capacity: a reaction to atherosclerosis?
- Current concepts in secondary prevention after acute myocardial infarction
- Effects of antioxidants on vascular health.
- beta-Carotene and selenium supplementation enhances immune response in aged humans.
- Risks of coronary heart disease in women: current understanding and evolving concepts.
- A summary of the science supporting the new National Cholesterol Education Program dietary recommendations: what dietitians should know.
- Education, lifestyle factors and mortality from cardiovascular disease and cancer. A 25-year follow-up of Swedish 50-year-old men.
- The oxidative stress hypothesis of congestive heart failure: radical thoughts.
- Comparison of baseline characteristics and mortality experience of participants and nonparticipants in a randomized clinical trial: the Physicians' Health Study.
- CAROTENOIDES Y SALUD HUMANA
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- Dietary antioxidants and paraoxonases against LDL oxidation and atherosclerosis development.
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