Screening for Microsatellite Instability in Colorectal Cancer and Lynch Syndrome - A Mini Review
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Summary
IHC is an easily accessible and cost effective approach with the advantage over MSI testing of being able to pinpoint the mutated gene, and is widely used as an initial primary test for detection of MSI-H tumors.
- Type
- review
- Published
- 2016-01-31
- Cited by
- 1
- References
- 61
- OpenAlex
- https://openalex.org/W2262292665
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:56567550
Keywords
Microsatellite instability, Lynch syndrome, Colorectal cancer, DNA mismatch repair, Germline mutation
References
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- WHO Classification of Tumours of the Digestive System
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- The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch Syndrome: from bench to bedside
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- Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene.
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- Immunohistochemistry staining for the mismatch repair proteins in the clinical care of patients with colorectal cancer
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