Wnt signaling and cancer.
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Summary
In this review, the wnt pathway will be covered from the perspective of cancer, with emphasis placed on molecular defects known to promote neoplastic transformation in humans and in animal models.
- Type
- article
- Published
- 2000-08-01
- Cited by
- 3,367
- References
- 198
- Access
- Open access
- OpenAlex
- https://openalex.org/W2239090104
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14960846
Keywords
Biology, Wnt signaling pathway, Signal transduction, Cancer research, Cancer
References
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- β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
- The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression.
- Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
- The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway
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- Beta-catenin mutation in carcinoma of the uterine endometrium.
Cited by
- Transcription factor regulation of B lineage commitment.
- Tumor Suppressor Pten Inhibits Nuclear Accumulation of β-Catenin and T Cell/Lymphoid Enhancer Factor 1–Mediated Transcriptional Activation
- E-cadherin regulates cell growth by modulating proliferation-dependent β-catenin transcriptional activity
- Disulfide Bond Assignments of Secreted Frizzled-related Protein-1 Provide Insights about Frizzled Homology and Netrin Modules*
- Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors
- A presenilin‐1/γ‐secretase cleavage releases the E‐cadherin intracellular domain and regulates disassembly of adherens junctions
- Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation.
- Associated proteins of lens adherens junction
- Armadillo levels are reduced during mitosis in Drosophila.
- LDL Receptor‐Related Proteins in Neurodevelopment
- Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated β-catenin
- Adherens junctions and cancer.
- Total Synthesis and Mechanism of Action Studies on the Antitumor Alkaloid (-)-Agelastatin A
- Impact of cytomorphological detection of circulating tumor cells in patients with liver cancer
- The ectodermal dysplasia receptor represses the Lef-1/beta-catenin-dependent transcription independent of NF-kappaB activation.
- Hindgut defects and transformation of the gastro‐intestinal tract in Tcf4−/−/Tcf1−/− embryos
- Multitasking in Tumor Progression: Signaling Functions of Cell Adhesion Molecules
- Stem cell origin of cancer and differentiation therapy.
- Chemoprevention by isothiocyanates and their underlying molecular signaling mechanisms.
- Roles of SCF and VHL ubiquitin ligases in regulation of cell growth.
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