The thrifty phenotype hypothesis.
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Summary
It is proposed that the epidemiological associations between poor fetal and infant growth and the subsequent development of type 2 diabetes and the metabolic syndrome result from the effects of poor nutrition in early life, which produces permanent changes in glucose-insulin metabolism.
- Type
- review
- Published
- 2001-11-01
- Cited by
- 2,736
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W2219578023
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18984832
Keywords
Insulin resistance, Obesity, Type 2 diabetes, Phenotype, Insulin
References
- The insulin gene VNTR, type 2 diabetes and birth weight
- Association between poor glucose tolerance and rapid post natal weight gain in seven-year-old children
- Birth Weight, Adult Weight, and Girth as Predictors of the Metabolic Syndrome in Postmenopausal Women: The Rancho Bernardo Study
- Fetal and infant growth and cardiovascular risk factors in women
- Fetal growth and hyperinsulinaemia in adult life
- Effects of size at birth and childhood growth on the insulin resistance syndrome in elderly individuals
- Birthweight and the Risk for Type 2 Diabetes Mellitus in Adult Women
- Childhood size is more strongly related than size at birth to glucose and insulin levels in 10–11-year-old children
- Birth weight and non-insulin dependent diabetes: thrifty genotype, thrifty phenotype, or surviving small baby genotype?
- The Fetal and Childhood Growth of Persons Who Develop Type 2 Diabetes
- Fetal Growth and Glucose and Insulin Metabolism in Four‐year‐old Indian Children
- Relation of size at birth to non-insulin dependent diabetes and insulin concentrations in men aged 50-60 years
- Birth weight, type 2 diabetes, and insulin resistance in Pima Indian children and young adults.
- Glucose tolerance and resistance to insulin-stimulated glucose uptake in men aged 70 years in relation to size at birth
- Association of the INS VNTR with size at birth
- Fetal and infant growth and impaired glucose tolerance at age 64.
- Birth weight and adult hypertension, diabetes mellitus, and obesity in US men.
- Low maternal birth weight—an association with impaired glucose tolerance in pregnancy
- Birth weight and cardiovascular risk factors in an epidemiological study
- Fetal growth and cardiovascular risk factors in Jamaican schoolchildren
Cited by
- Eating like a bird : long term effects of nutritional stress
- Insulin sensitivity and secretion in normal children related to size at birth, postnatal growth, and plasma insulin-like growth factor-I levels
- Low birthweight and Type 2 diabetes: a study on 11 162 Swedish twins.
- Insulin resistance syndrome in subjects with mutated RING finger protein TRIM37.
- Early renal structure alteration in rat offspring from dams fed low protein diet.
- Consequences of low birthweight on urinary excretion of DNA markers of oxidative stress in young men
- The Infant Development, Environment, and Lifestyle Study: Effects of Prenatal Methamphetamine Exposure, Polydrug Exposure, and Poverty on Intrauterine Growth
- Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis
- Diet and asthma: looking back, moving forward
- Reduced insulin secretion in protein malnourished mice is associated with multiple changes in the beta-cell stimulus-secretion coupling.
- Energetic basis of correlation between catch-up growth, health maintenance, and aging.
- Developmental origins of health and disease: experimental and human evidence of fetal programming for metabolic syndrome
- The metabolic and environmental determinants of obesity in childhood : observational and interventional studies
- Consequences of gestational and pregestational diabetes on placental function and birth weight.
- Epigenetic programming by maternal nutrition: shaping future generations.
- Labor Management and Mode of Delivery Among Migrant and Spanish Women: Does the Variability Reflect Differences in Obstetric Decisions According to Ethnic Origin?
- Epigenetics and chromatin dynamics: a review and a paradigm for functional disorders
- Omega-6 polyunsaturated fatty acids and the early origins of obesity
- Novel “Thrifty” Models of Increased Eating Behaviour
- Testing the evolutionary basis of the predictive adaptive response hypothesis in a preindustrial human population
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