Reducing myocardial infarct size: challenges and future opportunities
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Summary
The challenges facing clinical cardioprotection research are reviewed, future therapies for reducing MI size and preventing heart failure in patients presenting with STEMI at risk of myocardial reperfusion injury are highlighted.
- Type
- review
- Published
- 2015-12-16
- Cited by
- 228
- References
- 59
- Access
- Open access
- OpenAlex
- https://openalex.org/W2214990429
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13567303
Keywords
Medicine, Myocardial infarction, Cardiology, Internal medicine, Intensive care medicine
References
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- Myocardial Reperfusion Injury
- Transient limb ischemia induces remote ischemic preconditioning in vivo.
- Predicting late myocardial recovery and outcomes in the early hours of ST-segment elevation myocardial infarction traditional measures compared with microvascular obstruction, salvaged myocardium, and necrosis characteristics by cardiovascular magnetic resonance.
- Rationale and design of the EMBRACE STEMI study: a phase 2a, randomized, double-blind, placebo-controlled trial to evaluate the safety, tolerability and efficacy of intravenous Bendavia on reperfusion injury in patients treated with standard therapy including primary percutaneous coronary interventi
- Atrial natriuretic peptide administered just prior to reperfusion limits infarction in rabbit hearts
- Exenatide Reduces Final Infarct Size in Patients With ST-Segment–Elevation Myocardial Infarction and Short-Duration of Ischemia
- Randomised phase 2 trial of intra-coronary nitrite during acute myocardial infarction
- Regional Ischemic 'Preconditioning' Protects Remote Virgin Myocardium From Subsequent Sustained Coronary Occlusion
- Intracoronary injection of adenosine before reperfusion in patients with ST-segment elevation myocardial infarction: a randomized controlled clinical trial.
- Remote ischemic conditioning reduces myocardial infarct size and edema in patients with ST-segment elevation myocardial infarction.
- Prospective, Multicenter, Randomized, Controlled Pilot Trial of Peritoneal Hypothermia in Patients With ST-Segment—Elevation Myocardial Infarction
- The RIPOST-MI study, assessing remote ischemic perconditioning alone or in combination with local ischemic postconditioning in ST-segment elevation myocardial infarction
- Cardioprotection techniques: preconditioning, postconditioning and remote conditioning (basic science).
- Early Metoprolol Administration Before Coronary Reperfusion Results in Increased Myocardial Salvage: Analysis of Ischemic Myocardium at Risk Using Cardiac Magnetic Resonance
- Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction.
- Effect of cyclosporine on left ventricular remodeling after reperfused myocardial infarction.
- The mitochondrial permeability transition pore and its role in myocardial ischemia reperfusion injury.
Cited by
- Gender Differences in Factors Related to Prehospital Delay in Patients with ST-Segment Elevation Myocardial Infarction
- Targeting Ferroptosis by Polydopamine Nanoparticles Protects Heart against Ischemia/Reperfusion Injury.
- Pathobiology of Ischemic Heart Disease: Past, Present and Future.
- Moving Forwards by Blocking Back-Flow
- Natriuretic peptides in addition to Zwolle score to enhance safe and early discharge after acute myocardial infarction: A prospective observational cohort study.
- Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations
- Promising strategies to minimize reperfusion injury in STEMI.
- A critical review on the translational journey of cardioprotective therapies!
- The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge.
- Time to Give Up on Cardioprotection? A Critical Appraisal of Clinical Studies on Ischemic Pre-, Post-, and Remote Conditioning.
- TWEAK protects cardiomyocyte against apoptosis in a PI3K/AKT pathway dependent manner.
- Effect of intravenous and intracoronary melatonin as an adjunct to primary percutaneous coronary intervention for acute ST‐elevation myocardial infarction: Results of the Melatonin Adjunct in the acute myocaRdial Infarction treated with Angioplasty trial
- Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery
- miR‐192‐5p mediates hypoxia/reoxygenation‐induced apoptosis in H9c2 cardiomyocytes via targeting of FABP3
- Novel cardioprotective and regenerative therapies in acute myocardial infarction: a review of recent and ongoing clinical trials
- Controlled Reperfusion Strategies Improve Cardiac Hemodynamic Recovery after Warm Global Ischemia in an Isolated, Working Rat Heart Model of Donation after Circulatory Death (DCD)
- Melatonin for cardioprotection in ST elevation myocardial infarction: are we ready for the challenge?
- Prostaglandin E2 reduces swine myocardial ischemia reperfusion injury via increased endothelial nitric oxide synthase and vascular endothelial growth factor expression levels
- FGF-2 Transcriptionally Down-Regulates the Expression of BNIP3L via PI3K/Akt/FoxO3a Signaling and Inhibits Necrosis and Mitochondrial Dysfunction Induced by High Concentrations of Hydrogen Peroxide in H9c2 Cells
- Reperfusion injury in ST-segment elevation myocardial infarction: the final frontier.
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