Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling
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Summary
Current understanding of mammalian LATS1/2 kinases together with their closest relatives, the NDR1/1 kinases are summarized and the regulation of the LATS/NDR family of kinases will be discussed, followed by a summary of all currently known LATS-NDR substrates.
- Type
- article
- Published
- 2013-08-28
- Cited by
- 104
- References
- 156
- Access
- Open access
- OpenAlex
- https://openalex.org/W2169879898
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14656944
Keywords
Hippo signaling pathway, Kinase, Biology, Cell biology, Activator (genetics)
References
- The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis.
- KIBRA Regulates Hippo Signaling Activity via Interactions with Large Tumor Suppressor Kinases*
- Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction
- Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity
- Modulating F‐actin organization induces organ growth by affecting the Hippo pathway
- Hippo signaling in Drosophila: recent advances and insights
- Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation
- Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase.
- The tricornered gene, which is required for the integrity of epidermal cell extensions, encodes the Drosophila nuclear DBF2-related kinase.
- Mst1 and Mst2 maintain hepatocyte quiescence and suppress the development of hepatocellular carcinoma through inactivation of the Yap1 oncogene
- The human tumour suppressor LATS1 is activated by human MOB1 at the membrane.
- Homeodomain-interacting protein kinase regulates Yorkie activity to promote tissue growth.
- Genome-wide Identification of Post-translational Modulators of Transcription Factor Activity in Human B-Cells
- Regulation of Hippo signaling by EGFR-MAPK signaling through Ajuba family proteins
- MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1
- Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila.
- Mammalian Ste20-like Kinase (Mst2) Indirectly Supports Raf-1/ERK Pathway Activity via Maintenance of Protein Phosphatase-2A Catalytic Subunit Levels and Consequent Suppression of Inhibitory Raf-1 Phosphorylation*♦
- Mst2 and Lats Kinases Regulate Apoptotic Function of Yes Kinase-associated Protein (YAP)*
- An evolutionary shift in the regulation of the Hippo pathway between mice and flies
- TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
Cited by
- The Hippo pathway in disease and therapy: cancer and beyond
- NDR Kinases Are Essential for Somitogenesis and Cardiac Looping during Mouse Embryonic Development
- Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological Characteristics
- FAT1 cadherin acts upstream of Hippo signalling through TAZ to regulate neuronal differentiation
- Up-regulation of ITCH is associated with down-regulation of LATS1 during tumorigenesis and progression of cervical squamous cell carcinoma.
- The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy
- Structural basis for Mob1-dependent activation of the core Mst–Lats kinase cascade in Hippo signaling
- A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis
- YAP and TAZ: a nexus for Hippo signaling and beyond
- NDR Functions as a Physiological YAP1 Kinase in the Intestinal Epithelium
- Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device
- Binding of Kif23-iso1/CHO1 to 14-3-3 Is Regulated by Sequential Phosphorylations at Two LATS Kinase Consensus Sites
- Regulation of DNA damage responses and cell cycle progression by hMOB2
- The mammalian Hippo pathway: regulation and function of YAP1 and TAZ
- Constitutively active NDR1-PIF kinase functions independent of MST1 and hMOB1 signalling
- Pombe's thirteen – control of fission yeast cell division by the septation initiation network
- The non-canonical Hippo/Mst pathway in lymphocyte development and functions.
- Regulation of a LATS-homolog by Ras GTPases is important for the control of cell division
- Methylation‑associated inactivation of LATS1 and its effect on demethylation or overexpression on YAP and cell biological function in human renal cell carcinoma.
- Warts phosphorylates Mud to promote Pins-mediated mitotic spindle orientation in Drosophila independent of Yorkie
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