Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
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Summary
By focusing on activated cell circuitry, the approach outlined here provides insight into cancer biology not available at the chromosomal and transcriptional levels and can be applied broadly across all human cancers.
- Type
- article
- Published
- 2007-12-14
- Cited by
- 2,359
- References
- 53
- Access
- Open access
- OpenAlex
- https://openalex.org/W2168691181
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2316452
Keywords
Biology, Kinase, Lung cancer, Signal transduction, Cancer research
References
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- Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer.
- Oncogenic kinase signalling
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- Chasing mutations in the epidermal growth factor in lung cancer.
- A model for random sampling and estimation of relative protein abundance in shotgun proteomics.
- MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
- Enhanced analysis of metastatic prostate cancer using stable isotopes and high mass accuracy instrumentation.
- Cancer genes and the pathways they control
- Patterns of somatic mutation in human cancer genomes
- Signal transduction by receptors with tyrosine kinase activity.
- Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.
- ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines.
- The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272
- Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
- Gefitinib Induces Apoptosis in the EGFRL858R Non–Small-Cell Lung Cancer Cell Line H3255
Cited by
- Proteomic characterisation of chronic lymphocytic leukaemia cells treated with rituximab
- 肺鳞癌驱动基因研究进展
- ChimerDB 2.0—a knowledgebase for fusion genes updated
- Optimizing the Detection of Lung Cancer Patients Harboring Anaplastic Lymphoma Kinase (ALK) Gene Rearrangements Potentially Suitable for ALK Inhibitor Treatment
- Overview of the generation, validation, and application of phosphosite-specific antibodies.
- Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output.
- Quantitative proteome and phosphoproteome analysis of human pluripotent stem cells.
- Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression
- Mass spectrometry-based proteomics and network biology.
- The transcriptional landscape and mutational profile of lung adenocarcinoma
- Overcoming acquired resistance to kinase inhibition: the cases of EGFR, ALK and BRAF.
- Multiple reaction monitoring of multiple low-abundance transcription factors in whole lung cancer cell lysates.
- Regulation of connexin‐ and pannexin‐based channels by post‐translational modifications
- HIP1–ALK, a Novel Fusion Protein Identified in Lung Adenocarcinoma
- Small molecule discoidin domain receptor kinase inhibitors and potential medical applications.
- The efficacy of crizotinib in patients with ALK-positive nonsmall cell lung cancer
- Outcome of Crizotinib Treatment in a Young Woman with Heavily Pretreated ROS1-positive Lung Cancer
- EML4-ALK translocation is associated with early onset of disease and other clinicopathological features in Chinese female never-smokers with non-small-cell lung cancer
- Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia
- Consequences of Keratin Phosphorylation for Cytoskeletal Organization and Epithelial Functions.
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