Regulation of glutathione synthesis.
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Summary
Dysregulation of GSH synthesis is increasingly being recognized as contributing to the pathogenesis of many pathological conditions, including diabetes mellitus, pulmonary fibrosis, cholestatic liver injury, endotoxemia and drug-resistant tumor cells.
- Type
- review
- Published
- 2009-02-01
- Cited by
- 2,164
- References
- 230
- Access
- Open access
- OpenAlex
- https://openalex.org/W2166337262
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21620356
Keywords
GCLM, Glutathione, GCLC, GPX1, Oxidative stress
References
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- Amino acid sequence of rat kidney gamma-glutamylcysteine synthetase.
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- Mitigation strategies to ameliorate acute and chronic heat stress utilizing supplemental methionine or embryonic thermal conditioning in chickens
- Glutathione deficiency down-regulates hepatic lipogenesis in rats
- Functional analysis of glutathione and autophagy in response to oxidative stress
- The Redox Imbalance and the Reduction of Contractile Protein Content in Rat Hearts Administered with L-Thyroxine and Doxorubicin
- A Critical Appraisal of Advances in Pediatric Nonalcoholic Fatty Liver Disease
- Nicotinamide Adenine Dinucleotide (NAD+) Repletion Attenuates Bupivacaine-Induced Neurotoxicity
- Regulation of the Nrf2 antioxidant pathway by microRNAs: New players in micromanaging redox homeostasis.
- The effect of nC₆₀ on tissue distribution of ibuprofen in Cyprinus carpio.
- A new genome of Acidithiobacillus thiooxidans provides insights into adaptation to a bioleaching environment.
- Protection of Flos Lonicerae against acetaminophen-induced liver injury and its mechanism.
- Histopatological alterations and oxidative stress in liver and kidney of Leuciscus cephalus following exposure to heavy metals in the Tur River, North Western Romania.
- Glutathione maintenance is crucial for survival of melanocytes after exposure to rhododendrol
- Mathematical Modeling of the Methionine Cycle and Transsulfuration Pathway in Individuals with Autism Spectrum Disorder
- Libidibia ferrea presents antiproliferative, apoptotic and antioxidant effects in a colorectal cancer cell line.
- The AMPK-PGC-1α signaling axis regulates the astrocyte glutathione system to protect against oxidative and metabolic injury.
- Biochemical Mechanism of Rhododendrol-Induced Leukoderma
- NADPH-dependent and -independent Disulfide Reductase Systems
- Methylglyoxal modified IgG generates autoimmune response in rheumatoid arthritis.
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