The effect of age on prepro-orexin gene expression and contents of orexin A and B in the rat brain.
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Summary
Deterioration of the orexin system may play a role in the phenomenon associated with aging, e.g. decreased consolidation of vigilance states, endocrine changes and dysfunctions of autonomic nervous system.
- Type
- article
- Published
- 2004-02-01
- Cited by
- 76
- References
- 40
- OpenAlex
- https://openalex.org/W2165090993
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45586430
Keywords
Orexin, Orexin-A, Hypothalamus, Internal medicine, Endocrinology
References
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- Aging of the female reproductive system: a window into brain aging.
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- Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems.
- Orexins, orexigenic hypothalamic neuropeptides, suppress the pulsatile secretion of luteinizing hormone in ovariectomized female rats.
- Investigations into the neurologic basis of narcolepsy
- Diurnal variation in orexin A immunoreactivity and prepro-orexin mRNA in the rat central nervous system.
- Effects of lateral preoptic area application of orexin‐A on sleep–wakefulness
- Neuronal effects of orexins: relevant to sympathetic and cardiovascular functions.
- Distribution and quantification of immunoreactive orexin A in rat tissues
- Orexin A activates locus coeruleus cell firing and increases arousal in the rat.
- Sleep fragmentation in the elderly: relationship to daytime sleep tendency.
- Stimulation of gastric acid secretion by centrally administered orexin-A in conscious rats.
- Distribution of orexin receptor mRNA in the rat brain
- Radioimmunoassay of plasma progesterone.
- Fluctuation of extracellular hypocretin‐1 (orexin A) levels in the rat in relation to the light–dark cycle and sleep–wake activities
Cited by
- The diurnal rhythm of hypocretin in young and old F344 rats.
- Anorexia of aging.
- The novel role of the neuropeptides orexin and QRFP and their involvement in Alzheimer's disease
- The link between ageing and sleep disruption and their impact on cardiorespiratory control
- THE PUZZLE OF DECREASED HOMEOSTATIC SLOW WAVE SLEEP IN AGING
- Phospholipase Cascades in OX1 Orexin Receptor Signaling
- Central control of food intake in aging.
- Endoplasmic Reticulum Stress in Wake Active Neurons Progresses with Aging
- Age‐associated changes of appetite‐regulating peptides
- Orexin receptors exert a neuroprotective effect in Alzheimer’s disease (AD) via heterodimerization with GPR103
- Aging-related alterations in orexin/hypocretin modulation of septo-hippocampal amino acid neurotransmission
- Opposite effects of sleep rebound on orexin OX1 and OX2 receptor expression in rat brain.
- Sleep, its regulation and possible mechanisms of sleep disturbances
- Food for thought: The role of appetitive peptides in age-related cognitive decline
- Effects of changes in energy homeostasis and exposure of noxious insults on the expression of orexin (hypocretin) and its receptors in the brain.
- Disease and Degeneration of Aging Neural Systems that Integrate Sleep Drive and Circadian Oscillations
- Orexin-A does not stimulate food intake in old rats.
- Stimulation of cortical acetylcholine release by orexin A.
- Women's sleep in health and disease.
- Effects of orexins A and B on expression of orexin receptors and progesterone release in luteal and granulosa ovarian cells.
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