HMG-1 as a late mediator of endotoxin lethality in mice.
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Summary
High mobility group-1 (HMG-1) protein was found to be released by cultured macrophages more than 8 hours after stimulation with endotoxin, TNF, or IL-1, and showed increased serum levels after endotoxin exposure, suggesting that this protein warrants investigation as a therapeutic target.
- Type
- article
- Published
- 1999-07-09
- Cited by
- 3,568
- References
- 35
- OpenAlex
- https://openalex.org/W2164714222
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:85601983
Keywords
Mediator, Lethality, Tumor necrosis factor alpha, Lipopolysaccharide, Septic shock
References
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- From mouse to man: or what have we learned about cytokine-based anti-inflammatory therapies?
- Laboratory models of sepsis and septic shock.
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- Spermine Protects Mice Against Lethal Sepsis Partly by Attenuating Surrogate Inflammatory Markers
- [Expression of high mobility group box-1 in the lung tissue and BALF of asthmatic mice and the influence of dexamethasone].
- The timing of endothelin and nitric oxide inhibition affects survival in a mice model of septic shock.
- HMGB-1, a DNA-binding protein with cytokine activity, induces brain TNF and IL-6 production, and mediates anorexia and taste aversion.
- Disposal of dying cells: a balancing act between infection and autoimmunity.
- Failure of Monocytes of Trauma Patients to Convert to Immature Dendritic Cells is Related to Preferential Macrophage-Colony-Stimulating Factor-Driven Macrophage Differentiation1
- Temporal differences in the ability of ethanol to modulate endotoxin-induced increases in inflammatory cytokines in muscle under in vivo conditions.
- Converging actions of alcohol on liver and brain immune signaling.
- HMGB1‐secreting capacity of multiple cell lineages revealed by a novel HMGB1 ELISPOT assay
- Blockade of RAGE Suppresses Alloimmune Reactions In Vitro and Delays Allograft Rejection in Murine Heart Transplantation
- Early events in the recognition of danger signals after tissue injury
- HMGB1: Endogenous Danger Signaling
- The role of high mobility group box1 in pulmonary fibrosis.
- DANAPAROID SODIUM PREVENTS CERULEIN-INDUCED ACUTE PANCREATITIS IN RATS
- Molecular biology of inflammation and sepsis: A primer*
- Plasma Concentrations of High-Mobility Group Box Protein 1, Soluble Receptor for Advanced Glycation End-Products and Circulating DNA in Patients with Acute Pancreatitis
- High-Mobility Group Protein Box-1 and its Relevance to Cerebral Ischemia
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