Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus
Explore this paper's citation graph
Summary
The routine use of combination therapy with fenofibrate and simvastatin to reduce cardiovascular risk in the majority of high-risk patients with type 2 diabetes does not support the routine use.
- Type
- article
- Published
- 2010-03-14
- Cited by
- 2,712
- References
- 49
- Access
- Open access
- OpenAlex
- https://openalex.org/W2164324917
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18032950
Keywords
Medicine, Fenofibrate, Hazard ratio, Internal medicine, Simvastatin
References
- Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: design and methods.
- Effects of intensive glucose lowering in type 2 diabetes.
- Arch Intern Med:住院增加老年人出院后骨折危险
- MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial.
- Joint Effects of Serum Triglyceride and LDL Cholesterol and HDL Cholesterol Concentrations on Coronary Heart Disease Risk in the Helsinki Heart Study: Implications for Treatment
- Effects of Fenofibrate Treatment on Cardiovascular Disease Risk in 9,795 Individuals With Type 2 Diabetes and Various Components of the Metabolic Syndrome
- Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial.
- Diabetes, Other Risk Factors, and 12-Yr Cardiovascular Mortality for Men Screened in the Multiple Risk Factor Intervention Trial
- Impact of Diabetes on Mortality After the First Myocardial Infarction
- Heart Protection Study
- Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom prospective diabetes study (UKPDS: 23)
- Simvastatin Does Not Have a Clinically Significant Pharmacokinetic Interaction With Fenofibrate in Humans
- A More Accurate Method To Estimate Glomerular Filtration Rate from Serum Creatinine: A New Prediction Equation
- The independent effect of type 2 diabetes mellitus on ischemic heart disease, stroke, and death: a population-based study of 13,000 men and women with 20 years of follow-up.
- Effect of fenofibrate-mediated increase in plasma homocysteine on the progression of coronary artery disease in type 2 diabetes mellitus.
- Evolution of the lipid trial protocol of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.
- Reporting rate of rhabdomyolysis with fenofibrate + statin versus gemfibrozil + any statin.
- Prevention of cardiovascular disease in persons with type 2 diabetes mellitus: current knowledge and rationale for the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.
- Rationale and design for the blood pressure intervention of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.
- Prevention of the angiographic progression of coronary and vein-graft atherosclerosis by gemfibrozil after coronary bypass surgery in men with low levels of HDL cholesterol. Lopid Coronary Angiography Trial (LOCAT) Study Group.
Cited by
- The AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes) trial: to believe or not to believe?
- Paradoxical negative HDL cholesterol response to atorvastatin and simvastatin treatment in Chinese type 2 diabetic patients.
- Therapeutic Potential of Aleglitazar, a New Dual PPAR-α/γ Agonist
- Cardiovascular outcomes in type 2 diabetes: the impact of preventative therapies
- Pharmacokinetics, efficacy and safety of aleglitazar for the treatment of type 2 diabetes with high cardiovascular risk
- Metabolic syndrome: nature, therapeutic solutions and options
- A physician's guide for the management of hypertriglyceridemia: the etiology of hypertriglyceridemia determines treatment strategy.
- The Renoprotective Actions of Peroxisome Proliferator-Activated Receptors Agonists in Diabetes
- Fibrates: therapeutic potential for diabetic nephropathy?
- The Effect of Fenofibrate on Lymphocyte Release of Proinflammatory Cytokines and Systemic Inflammation in Simvastatin‐Treated Patients with Atherosclerosis and Early Glucose Metabolism Disturbances
- Fibrates are an essential part of modern anti-dyslipidemic arsenal: spotlight on atherogenic dyslipidemia and residual risk reduction
- Peroxisome Proliferator–Activated Receptor-α Agonism With Fenofibrate Does Not Suppress Inflammatory Responses to Evoked Endotoxemia
- Simvastatin and amlodipine induced thrombocytopenia in the same patient: double trouble and a literature review
- A Clinician's Guide to the ABCs of Cardiovascular Disease Prevention: The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease and American College of Cardiology Cardiosource Approach to the Million Hearts Initiative
- Update Fettstoffwechselstörungen
- High-density lipoproteins: a consensus statement from the National Lipid Association.
- Paradox of using intensive lowering of blood glucose in diabetics and strategies to overcome it and decrease cardiovascular risks
- Use of fibrates in the metabolic syndrome: A review.
- Intensive LDL Reduction Post Acute Coronary Syndromes: A Catalyst for Improved Outcomes.
- Pathophysiology and treatment of atherosclerosis
Related papers
- Clinical observation of simvastatin and fenofibrate in the treatment of type 2 diabetes with hyperlipemia
- Lipoprotein particle analysis comparing simvastatin and fenofibrate.
- Observation on the Treatment of Mixed Hyperlipidemia with Simvastatin and Fenofibrate Together
- New Fixed-Dose Combinations of Fenofibrate/Simvastatin Therapy Significantly Improve the Lipid Profile of High-Risk Patients with Mixed Dyslipidemia Versus Monotherapies.
- [The efficacy and tolerance of simvastatin and fenofibrate in primary hypercholesterolemia].
- Iatrogenic Severe Depression of High‐Density Lipoprotein Cholesterol
- Rotavirus vax averts illness in Latin American infants
- Effects of simvastatin and fenofibrate on the expression of apolipoprotein M
- Fenofibrate, simvastatin and their combination in the management of dyslipidaemia in type 2 diabetic patients
- Effects and mechanism of simvastatin and fenofibrate on the expression of hepatic apolipoprotein M in mice