Chemotherapy of leishmaniasis: past, present and future.
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Summary
The present review describes the current understanding of different drugs against leishmaniasis, their chemistry, mode of action and the mechanism of resistance in the parasite.
- Type
- review
- Published
- 2007-03-31
- Cited by
- 278
- References
- 131
- OpenAlex
- https://openalex.org/W2163318403
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21091899
Keywords
Miltefosine, Leishmaniasis, Pentamidine, Leishmania donovani, Paromomycin
References
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- Use of a new bioassay to study pentamidine pharmacokinetics.
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- Studies on the mode of action of excess of vitamin A. 9. Penetration of lipid monolayers by compounds in the vitamin A series.
- New developments in diagnosis of leishmaniasis.
- Ether lipid metabolism, GPI anchor biosynthesis, and signal transduction are putative targets for anti-leishmanial alkyl phospholipid analogues.
- Multiple drug resistance and conservative amplification of the H region in Leishmania major.
- Effects of hexadecylphosphocholine on cellular function.
- Proteases of protozoan parasites.
- Selective destruction of human leukemic cells by alkyl-lysophospholipids.
- Luteolin, an Abundant Dietary Component is a Potent Anti-leishmanial Agent that Acts by Inducing Topoisomerase II-mediated Kinetoplast DNA Cleavage Leading to Apoptosis
- Destruction of human solid tumors by alkyl lysophospholipids.
- Characterization of the Antimonial Antileishmanial Agent Meglumine Antimonate (Glucantime)
- Plant natural products with leishmanicidal activity.
- Parasite-specific trypanothione reductase as a drug target molecule
- Altered transport properties of pentamidine-resistant Leishmania donovani and L. amazonensis promastigotes
- Ether--lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether--lipid analogues in Leishmania.
- Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica.
- Efficacy of anticancer alkylphosphocholines in Trypanosoma brucei subspecies.
- Challenges and new discoveries in the treatment of leishmaniasis
Cited by
- Antileishmanial effect of new indeno-1,5-naphthyridines, selective inhibitors of Leishmania infantum type IB DNA topoisomerase.
- Comparative Chemical, Cytotoxicity and Antileishmanial Properties of Essential Oils from Chenopodium ambrosioides
- Study of the secretome of leishmania involved in the infection
- Antileishmanial activity of Allicin: mechanism of action, "in vivo" efficacy and value in combined therapy with Amphotericin B
- Alkaloids with antiprotozoal activity.
- Interventions for American cutaneous and mucocutaneous leishmaniasis.
- Screening for Inhibitors of Essential Leishmania Glucose Transporters
- Paromomycin-loaded albumin microspheres: efficacy and stability studies.
- Study on the roles of O-acetylserine (thiol) lyase and thiol dependent reductase 1 of Leishmania
- Caracterización de las proteínas LABCG1 y LABCG5 de Leishmania: implicación en el tráfico intracelular de hemo y en la infección de macrófagos
- Obtenção de derivados dos terpenos enidrina e afidicolina por biotransformação e semi-síntese e avaliação da atividade leishmanicida
- A pilot study comparing low‐dose liposomal amphotericin B with N‐methyl glucamine for the treatment of American cutaneous leishmaniasis
- Pharmacotherapeutic Options for Visceral Leishmaniasis—Current Scenario
- Mitochondrial Proteomics of Antimony and Miltefosine Resistant Leishmania infantum
- Chemoinformatics: Directions Toward Combating Neglected Diseases
- New Approaches to the Development of Anti-Protozoan Vaccine and Drug Candidates: A Review of Patents
- Chemotherapeutic efficacy and safety of diminazene aceturate-chloroquine sulphate combination as an antileishmanial drug in balb /c mice
- The Effect of Garlic Extract on Expression of INFγ And Inos Genes in Macrophages Infected with Leishmania major
- Interventions for visceral leishmaniasis
- Oral miltefosine in post‐kala‐azar dermal leishmaniasis – experience in three cases
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