Enhanced repair of cyclobutane pyrimidine dimers and improved UV resistance in photolyase transgenic mice
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Summary
Providing mice with CPD photolyase significantly improves repair and uncovers the biological effects of CPD lesions, suggesting the presence of intercellular apoptotic signals.
- Type
- article
- Published
- 2002-09-02
- Cited by
- 103
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W2160986283
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6253992
Keywords
Photolyase, Pyrimidine dimer, Biology, Nucleotide excision repair, DNA repair
References
- DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall.
- Blockage of RNA polymerase as a possible trigger for u.v. light-induced apoptosis.
- The Metabolic and Molecular Bases of Inherited Disease
- Photoreactivation of ultraviolet radiation-induced skin and eye tumors of Monodelphis domestica.
- Clinical heterogeneity within xeroderma pigmentosum associated with mutations in the DNA repair and transcription gene ERCC3.
- Isolation and utilization of epidermal keratinocytes for oncogene research.
- A new class of DNA photolyases present in various organisms including aplacental mammals.
- Transcription‐coupled repair removes both cyclobutane pyrimidine dimers and 6‐4 photoproducts with equal efficiency and in a sequential way from transcribed DNA in xeroderma pigmentosum group C fibroblasts.
- Cyclobutane Pyrimidine Dimers Are Responsible for the Vast Majority of Mutations Induced by UVB Irradiation in Mammalian Cells*
- SIMULTANEOUS ESTABLISHMENT OF MONOCLONAL ANTIBODIES SPECIFIC FOR EITHER CYCLOBUTANE PYRIMIDINE DIMER OR (6‐4)PHOTOPRODUCT FROM THE SAME MOUSE IMMUNIZED WITH ULTRAVIOLET‐IRRADIATED DNA
- THE RELATIVE CYTOTOXICITY OF(6–4) PHOTOPRODUCTS AND CYCLOBUTANE DIMERS IN MAMMALIAN CELLS *
- Detection of the Philadelphia chromosome in interphase nuclei.
- Death receptors in cutaneous biology and disease.
- Evasion of UVC-induced apoptosis by photorepair of cyclobutane pyrimidine dimers.
- Repair of pyrimidine(6-4)pyrimidone photoproducts in mouse skin.
- Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA
- Light-induced apoptosis
- DNA repair after ultraviolet irradiation of ICR 2A frog cells. Pyrimidine dimers are long acting blocks to nascent DNA synthesis.
- Photoreactivation of UV induced cell killing, chromosome aberrations, sister chromatid exchanges, mutations and pyrimidine dimers in Xenopus laevis fibroblasts
- High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene
Cited by
- Xeroderma pigmentosum group C sensor: unprecedented recognition strategy and tight spatiotemporal regulation
- Strukturbasierte Charakterisierung von Klasse II CPD Photolyasen
- DNA mismatch repair and the cellular response to UVC radiation
- Cytotoxic, mutagenic and carcinogenic properties of ultraviolet radiation : shining light on photolesions
- Baculoviral and marsupial CPD photolyases: DNA repair proteins with a circadian clock function
- Functional Analysis of Mammalian Cryptochromes: a matter of time
- Papel biológico dos dímeros de pirimidina em células humanas irradiadas com radiação UVA Biological role of pyrimidine dimers in human cells irradiated with UVA radiation
- Estudos de reparo de DNA por excisão de nucleotídeos em lesões oxidativas em células de mamíferos.
- Crystal structures of an archaeal class II DNA photolyase and its complex with UV‐damaged duplex DNA
- Differential biologic effects of CPD and 6-4PP UV-induced DNA damage on the induction of apoptosis and cell-cycle arrest
- Human papillomavirus mediated inhibition of DNA damage sensing and repair drives skin carcinogenesis
- det1-1-induced UV-C hyposensitivity through UVR3 and PHR1 photolyase gene over-expression.
- Repair of UV lesions in nucleosomes--intrinsic properties and remodeling.
- 50 years thymine dimer.
- Transfection of pseudouridine-modified mRNA encoding CPD-photolyase leads to repair of DNA damage in human keratinocytes: a new approach with future therapeutic potential
- Powerful skin cancer protection by a CPD-photolyase transgene.
- DNA Repair in Mammalian Cells
- Preventive Long-Term Effects of a Topical Film-Forming Medical Device with Ultra-High UV Protection Filters and DNA Repair Enzyme in Xeroderma Pigmentosum: A Retrospective Study of Eight Cases
- Prophylaxis of oxidative DNA damage by formamidopyrimidine‐DNA glycosylase
- Mechanisms of DNA damage recognition and strand discrimination in human nucleotide excision repair.
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