The control of tissue architecture over nuclear organization is crucial for epithelial cell fate
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Summary
It is shown that induction of partial differentiation by epigenetic mechanisms in malignant breast cells is sufficient to restore features of differentiation-specific nuclear organization, including perinucleolar heterochromatin, large splicing factor speckles, and distinct nuclear mitotic apparatus protein (NuMA) foci.
- Type
- article
- Published
- 2007-05-01
- Cited by
- 72
- References
- 69
- OpenAlex
- https://openalex.org/W2160760173
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:260592
Keywords
Biology, Cell biology, Mitosis, Cellular differentiation, Epigenetics
References
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Cited by
- Interconnected contribution of tissue morphogenesis and the nuclear protein NuMA to the DNA damage response
- Nuclear Matrix in Apoptotic Cell Death and Cell Proliferation. The role of Nuclear Mitotic Apparatus (NuMA) Protein
- Three-Dimensional Culture of Human Breast Epithelial Cells: The How and the Why
- Altered cholesterol metabolism in human cancers unraveled by label-free spectroscopic imaging
- Tight Junctions in Cancer Metastasis
- The Biomechanical Properties of 3d Extracellular Matrices and Embedded Cells Regulate the Invasiveness of Cancer Cells
- Statistical Analysis of 3D Images Detects Regular Spatial Distributions of Centromeres and Chromocenters in Animal and Plant Nuclei
- Epithelial cell polarity and tumorigenesis: new perspectives for cancer detection and treatment
- Parsing the early cytoskeletal and nuclear organizational cues that demarcate stem cell lineages
- Tissue Polarity-Dependent Control of Mammary Epithelial Homeostasis and Cancer Development: an Epigenetic Perspective
- Label-free analysis of breast tissue polarity by Raman imaging of lipid phase.
- Urothelial dysplasia and other flat lesions of the urinary bladder: clinicopathologic and molecular features.
- Modeling the 3D functional architecture of the nucleus in animal and plant kingdoms.
- Specific positioning of the casein gene cluster in active nuclear domains in luminal mammary epithelial cells
- Epigenetic Modifications in 3D: Nuclear Organization of the Differentiating Mammary Epithelial Cell
- The nucleoplasmic reticulum: form and function.
- Label-free spectroscopic detection of membrane potential using stimulated Raman scattering
- Polarity Proteins as Regulators of Cell Junction Complexes: Implications for Breast Cancer
- MUC1: A Novel Metabolic Master Regulator
- Factors necessary to produce basoapical polarity in human glandular epithelium formed in conventional and high-throughput three-dimensional culture: example of the breast epithelium
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