Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
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Summary
This study randomly assigned patients who arrived at an urban emergency department with severe sepsis or septic shock to receive either six hours of early goal-directed therapy or standard therapy (as a control) before admission to the intensive care unit.
- Type
- article
- Published
- 2001-11-08
- Cited by
- 8,880
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W2160691650
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7549555
Keywords
Medicine, Early goal-directed therapy, Septic shock, Preload, Intensive care medicine
References
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- Central Venous Oxygen Saturation in Shock: A Study in Man
- Clinical trials for severe sepsis. Past failures, and future hopes.
- Insertion time of the pulmonary artery catheter in critically ill patients
- Mechanism of inappropriate polyuria in septic patients.
- Comparison of central-venous to mixed-venous oxygen saturation during changes in oxygen supply/demand.
- Manipulating hemodynamics and oxygen transport in critically ill patients.
- Resuscitation of the critically ill in the ED: responses of blood pressure, heart rate, shock index, central venous oxygen saturation, and lactate.
- Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
- Interim analysis: the alpha spending function approach.
- APACHE II: A severity of disease classification system
- Septic shock: an analysis of outcomes for patients with onset on hospital wards versus intensive care units.
- Importance of the sampling site for measurement of mixed venous oxygen saturation in shock.
- Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome.
Cited by
- Protocolized Care for Early Septic Shock (ProCESS) statistical analysis plan
- Pneumonies associées à la ventilation mécanique : faut-il suivre les recommandations ?
- Steroids for patients in septic shock: the results of the CORTICUS trial.
- Therapiestrategien des Post-Reanimationssyndromes
- Hemodynamic goal-directed therapy. A review
- Kidney injury: the case of elderly patients
- Nahinfrarotspektroskopie in der Sepsistherapie
- Metabolic complications of severe malaria.
- Prise en charge des états septiques sévères chez l’adulte aux urgences
- Goal-oriented shock resuscitation for major torso trauma: What are we learning?
- Evidence based evaluation of immuno-coagulatory interventions in critical care.
- Non-invasive Sepsis Patient Classification using Least Squares Support Vector Machine
- Mixed and central venous oxygen saturation are not interchangeable in patients with cardiogenic shock after cardiac surgery
- Role of vasopressin in the management of septic shock
- A proposed scoring system for predicting mortality in melioidosis.
- Management of severe sepsis and septic shock
- Pathophysiology of polytrauma.
- Venous oximetry
- Preconditioning of primary human endothelial cells with inflammatory mediators alters the “set point” of the cell
- Antithrombotic therapies for sepsis: A need for more studies*
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