Evidence for Soft Selective Sweeps in the Evolution of Pneumococcal Multidrug Resistance and Vaccine Escape

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Summary

The rapid diversification through homologous recombination seen in the global collection was similarly observed in the absence of vaccination in a set of isolates from the Maela refugee camp in Thailand, a collection that also allowed variation to be observed within carriage through longitudinal sampling, suggesting that some pneumococcal genotypes generate a pool of standing variation that is sufficiently extensive to result in “soft” selective sweeps.

Type
article
Published
2014-06-10
Cited by
116
References
64
Access
Open access

Keywords

Biology, Serotype, Streptococcus pneumoniae, Pneumococcal conjugate vaccine, Multilocus sequence typing

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