Evidence for Soft Selective Sweeps in the Evolution of Pneumococcal Multidrug Resistance and Vaccine Escape
Explore this paper's citation graph
Summary
The rapid diversification through homologous recombination seen in the global collection was similarly observed in the absence of vaccination in a set of isolates from the Maela refugee camp in Thailand, a collection that also allowed variation to be observed within carriage through longitudinal sampling, suggesting that some pneumococcal genotypes generate a pool of standing variation that is sufficiently extensive to result in “soft” selective sweeps.
- Type
- article
- Published
- 2014-06-10
- Cited by
- 116
- References
- 64
- Access
- Open access
- OpenAlex
- https://openalex.org/W2160193310
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1019309
Keywords
Biology, Serotype, Streptococcus pneumoniae, Pneumococcal conjugate vaccine, Multilocus sequence typing
References
- Serotype 19F Multiresistant Pneumococcal Clone Harboring Two Erythromycin Resistance Determinants [erm(B) and mef(A)] in South Africa
- Genetic Relatedness of the Streptococcus pneumoniae Capsular Biosynthetic Loci
- Biopython: freely available Python tools for computational molecular biology and bioinformatics
- Tn5253, the pneumococcal omega (cat tet) BM6001 element, is a composite structure of two conjugative transposons, Tn5251 and Tn5252
- Mutations in the dihydrofolate reductase gene of trimethoprim-resistant isolates of Streptococcus pneumoniae
- Clonal replacement among 19A Streptococcus pneumoniae in Massachusetts, prior to 13 valent conjugate vaccination
- Evolution of MRSA During Hospital Transmission and Intercontinental Spread
- Effect of introduction of the pneumococcal conjugate vaccine on drug-resistant Streptococcus pneumoniae.
- Genomic Analyses of Clonal Isolates Provide Clues to the Evolution of Streptococcus pneumoniae
- Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species
- Allelic variation in the highly polymorphic locus pspC of Streptococcus pneumoniae.
- Carried Pneumococci in Massachusetts Children; The Contribution of Clonal Expansion and Serotype Switching
- Dense genomic sampling identifies highways of pneumococcal recombination
- A Longitudinal Study of Streptococcus pneumoniae Carriage in a Cohort of Infants and Their Mothers on the Thailand-Myanmar Border
- The Macrolide Resistance Genes erm(B) and mef(E) Are Carried by Tn2010 in Dual-Gene Streptococcus pneumoniae Isolates Belonging to Clonal Complex CC271
- Identifying Currents in the Gene Pool for Bacterial Populations Using an Integrative Approach
- Mosaic pbpX genes of major clones of penicillin‐resistant Streptococcus pneumoniae have evolved from pbpX genes of a penicillin‐sensitive Streptococcus oralis
- Genome-wide dissection of globally emergent multi-drug resistant serotype 19A Streptococcus pneumoniae
- Antimicrobial resistance in Streptococcus pneumoniae: an overview.
- Basic local alignment search tool.
Cited by
- Genetic Analyses of Penicillin Binding Protein Determinants in Multidrug-Resistant Streptococcus pneumoniae Serogroup 19 CC320/271 Clone with High-Level Resistance to Third-Generation Cephalosporins
- Evolving pneumococcal serotypes and sequence types in relation to high antibiotic stress and conditional pneumococcal immunization
- Rapid phylogenetic analysis of large samples of recombinant bacterial whole genome sequences using Gubbins
- Mechanisms of genome evolution of Streptococcus
- Selective and Genetic Constraints on Pneumococcal Serotype Switching
- Diversification of bacterial genome content through distinct mechanisms over different timescales
- The population genetics of drug resistance evolution in natural populations of viral, bacterial and eukaryotic pathogens
- Population genomic datasets describing the post-vaccine evolutionary epidemiology of Streptococcus pneumoniae
- Rationale and prospects for novel pneumococcal vaccines
- Genomic perspectives on the evolution and spread of bacterial pathogens
- Horizontal DNA Transfer Mechanisms of Bacteria as Weapons of Intragenomic Conflict
- Cocolonization of Pneumococcal Serotypes in Healthy Children Attending Day Care Centers: Molecular Versus Conventional Methods
- Biological and Epidemiological Features of Antibiotic-Resistant Streptococcus pneumoniae in Pre- and Post-Conjugate Vaccine Eras: a United States Perspective
- In vitro activity of dalbavancin against multidrug-resistant Staphylococcus aureus and streptococci from patients with documented infections in Europe and surrounding regions (2011-2013).
- Epigenetic Switch Driven by DNA Inversions Dictates Phase Variation in Streptococcus pneumoniae
- Pherotype polymorphism in Streptococcus pneumoniae and its effects on population structure and recombination
- Diverse evolutionary patterns of pneumococcal antigens identified by pangenome-wide immunological screening
- Frequent recombination of pneumococcal capsule highlights future risks of emergence of novel serotypes
- Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis
- New Aspects of the Interplay between Penicillin Binding Proteins, murM, and the Two-Component System CiaRH of Penicillin-Resistant Streptococcus pneumoniae Serotype 19A Isolates from Hungary
Related papers
- Study on serotype distribution in 48 isolates of invasive Streptococcus pneumoniae with which children infected
- MLST based serotype prediction for the accurate identification of non typhoidal Salmonella serovars
- Evaluation of Serotype Prediction bycpsA-cpsB Gene Polymorphism inStreptococcus pneumoniae
- First report of an outbreak of pneumonia caused by Streptococcus pneumoniae serotype 6A
- Serotyping of Streptococcus pneumoniae isolated from Tehran by Multiplex PCR: Are serotypes of clinical and carrier isolates identical?
- Serotyping of Streptococcus pneumoniae strains by coagglutination.
- Distribution and Invasiveness of Streptococcus pneumoniae Serotypes in Switzerland, a Country with Low Antibiotic Selection Pressure, from 2001 to 2004
- Serotypes of Streptococcus pneumoniae causing meningitis in southern India. Use of new direct latex agglutination antigen detection tests in cerebrospinal fluid.
- First report of Streptococcus pneumoniae serotype 6D isolates from invasive infections.