Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition
Explore this paper's citation graph
Summary
Characterization of the two COX isozymes is allowing the discrimination of the roles each play in physiological processes such as homeostatic maintenance of the gastrointestinal tract, renal function, blood clotting, embryonic implantation, parturition, pain, and fever.
- Type
- review
- Published
- 2004-09-01
- Cited by
- 1,750
- References
- 595
- OpenAlex
- https://openalex.org/W2158960911
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1917593
Keywords
Cyclooxygenase, Isozyme, Pharmacology, Inflammation, Prostaglandin
References
- Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis.
- Comparison of the effects of etodolac SR and naproxen on gastro-intestinal blood loss.
- In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis.
- A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.
- Prostaglandins, aspirin-like drugs and analgesia.
- Cyclo‐oxygenase and nitric oxide synthase isoforms in rat carrageenin‐induced pleurisy
- A p38 MAP kinase inhibitor regulates stability of interleukin‐1‐induced cyclooxygenase‐2 mRNA
- Salt–sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor
- Relationship of nimesulide safety to its pharmacokinetics: assessment of adverse reactions.
- Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trial.
- Inhibition of neutrophil function in vitro by nimesulide. Preliminary evidence of an adenosine-mediated mechanism.
- An overview of the efficacy of etodolac in arthritic disorders.
- Efficacy and safety of meloxicam in patients with rheumatoid arthritis.
- Double blind evaluation of the long-term effects of etodolac versus ibuprofen in patients with rheumatoid arthritis.
- Effect of specific COX-2 inhibition in osteoarthritis of the knee: a 6 week double blind, placebo controlled pilot study of rofecoxib. Rofecoxib Osteoarthritis Pilot Study Group.
- Induction of endothelial cell cytoplasmic lipid bodies during hypoxia.
- Etodolac (Lodine) in the treatment of osteoarthritis: recent studies.
- Efficacy and Tolerability of Meloxicam versus Piroxicam in Patients with Osteoarthritis of the Hip or Knee
- Cyclooxygenase knockout mice: models for elucidating isoform-specific functions.
- Expression of the murine prostaglandin (PGH) synthase-1 and PGH synthase-2 isozymes in cos-1 cells.
Cited by
- Discovery and characterization of inflammation-induced electrophilic fatty acid derivatives
- Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in adjuvant-induced arthritis in female albino rats: an isobolographic study.
- Contributions of Histamine, Prostanoids, and Neurokinins to Edema Elicited by Edema Toxin from Bacillus anthracis
- Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX‐2
- NSAIDs: small molecules for prevention of Alzheimer's disease or precursors for future drug development?
- Comparison of Caspase Genes for the Induction of Apoptosis Following Gene Delivery
- Prostaglandin E2 prevents Helicobacter-induced gastric preneoplasia and facilitates persistent infection in a mouse model.
- IL-1β Stimulates COX-2 Dependent PGE2 Synthesis and CGRP Release in Rat Trigeminal Ganglia Cells
- Calcium signaling in cerebral vasoregulation.
- Immunological role of prostaglandin E2 production in mouse auditory cells in response to LPS
- Role of 15-hydroxyprostaglandin dehydrogenase down-regulation on the prognosis of hepatocellular carcinoma
- Luteinizing Hormone-Induced Expression of Ptger4b, a Prostaglandin E2 Receptor Indispensable for Ovulation of the Medaka Oryzias latipes, Is Regulated by a Genomic Mechanism Involving Nuclear Progestin Receptor1
- Metabolic profiling of Commiphora wightii (guggul) reveals a potential source for pharmaceuticals and nutraceuticals.
- Challenges to develop novel anti-inflammatory and analgesic drugs.
- Effect of Non-Steroidal Anti-Inflammatory Drugs on Bone Healing
- Low-dose aspirin use and survival in breast cancer patients: A nationwide cohort study.
- Fibrodysplasia ossificans progressiva: Basic understanding and experimental models.
- PGE2 inhibits spermatogonia differentiation in zebrafish: interaction with Fsh and an androgen.
- Meloxicam and Dexamethasone Administration as Anti-Inflammatory Compounds to Sows Prior to Farrowing Does Not Improve Lactation Performance
- Inhibitors of cyclooxygenases: mechanisms, selectivity and uses.
Related papers
- The cyclooxygenase isoforms: structural insights into the conversion of arachidonic acid to prostaglandins.
- Cyclooxygenase activity in chondrocytes from osteoarthritic and healthy cartilage.
- Estimation of the in vivo effect of cyclooxygenase inhibitors on prostaglandin E2 levels in mouse brain.
- Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair.
- Effect of spinal cyclooxygenase inhibitors in rat using the formalin test and in vitro prostaglandin E2 release.
- Prostaglandin E2 increases the expression of cyclooxygenase-2 protein in microglia.
- Prostaglandin D2 and prostaglandin E2 accelerate the recovery of cutaneous barrier disruption induced by mechanical scratching in mice.
- Induction of cyclooxygenase-2 is responsible for interleukin-1 beta-dependent prostaglandin E2 synthesis by human lung fibroblasts.
- Effects of non-steroidal anti-inflammatory drugs on prostaglandin E2 production by cyclooxygenase-2 from endogenous and exogenous arachidonic acid in rat peritoneal macrophages stimulated with lipopolysaccharide.
- Prostaglandin synthesis and catabolism in the gastric mucosa: studies in normal rabbits and rabbits immunized with prostaglandin E2.