Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
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Summary
A broad, drug-like phase II metabolic response of the host to metabolites generated by the microbiome was observed, suggesting that the gut microflora has a direct impact on the drug metabolism capacity of theHost.
- Type
- article
- Published
- 2009-03-10
- Cited by
- 2,550
- References
- 45
- Access
- Open access
- OpenAlex
- https://openalex.org/W2155897723
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8336084
Keywords
Metabolomics, Gut flora, Biology, Bacteria, Microbial metabolism
References
- Diagnosis of medium chain acyl-CoA dehydrogenase deficiency by stable isotope dilution analysis of urinary acylglycines: retrospective and prospective studies, and comparison of its accuracy to acylcarnitine identification by FAB/mass spectrometry.
- XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification.
- Accumulation of furancarboxylic acids in uremic serum as inhibitors of drug binding.
- Host-Bacterial Mutualism in the Human Intestine
- The Enzymatic Basis for the Dehydrogenation of 3-Phenylpropionic Acid: In Vitro Reaction of 3- Phenylpropionyl-CoA with Various Acyl-CoA Dehydrogenases
- Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes
- Development of indole-3-propionic acid (OXIGON™) for alzheimer’s disease
- Formation of Phenolic and Indolic Compounds by Anaerobic Bacteria in the Human Large Intestine
- The end products of the metabolism of aromatic amino acids by clostridia
- Potent Neuroprotective Properties against the Alzheimer β-Amyloid by an Endogenous Melatonin-related Indole Structure, Indole-3-propionic Acid*
- Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome
- Identification of sulfation sites of metabolites and prediction of the compounds’ biological effects
- Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome.
- Multiple ionization mass spectrometry strategy used to reveal the complexity of metabolomics.
- Serotonin and Its Role in Colonic Function and in Gastrointestinal Disorders
- Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney.
- Bile salt biotransformations by human intestinal bacteria Published, JLR Papers in Press, November 18, 2005.
- Indole‐3‐propionic acid, a melatonin‐related molecule, protects hepatic microsomal membranes from iron‐induced oxidative damage: Relevance to cancer reduction
- An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system.
- Solvent-dependent metabolite distribution, clustering, and protein extraction for serum profiling with mass spectrometry.
Cited by
- Metabolism in chronic fatigue syndrome.
- Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short chain fatty acid-producing intestinal microbiota in ESRD
- Symbiosis as the way of eukaryotic life: The dependent co-origination of the body
- Nonextracorporeal methods for decreasing uremic solute concentration: a future way to go?
- Interactive XCMS Online: Simplifying Advanced Metabolomic Data Processing and Subsequent Statistical Analyses
- An n=1 case report of a child with autism improving on antibiotics and a father's quest to understand what it may mean
- Untargeted analysis of sesquiterpene pyridine alkaloids from the dried roots of Tripterygium wilfordii using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry.
- Roles of indole as an interspecies and interkingdom signaling molecule.
- Sex-Specific Effects of Organophosphate Diazinon on the Gut Microbiome and Its Metabolic Functions
- Microbiome-wide association studies link dynamic microbial consortia to disease
- Modeling Longitudinal Metabonomics and Microbiota Interactions in C57BL/6 Mice Fed a High Fat Diet.
- Human Metabolome-derived Cofactors Are Required for the Antibacterial Activity of Siderocalin in Urine
- Involvement of a gut–retina axis in protection against dietary glycemia-induced age-related macular degeneration
- Gut microbiota and probiotics intervention: A potential therapeutic target for management of cardiometabolic disorders and chronic kidney disease?
- Role of Gut Microbiota-Gut Hormone Axis in the Pathophysiology of Functional Gastrointestinal Disorders
- The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders
- Bacterial butyrate prevents atherosclerosis
- Comparison of two types of vinegar with different aging times by NMR-based metabolomic approach.
- Pathophysiologic Role of Neurotransmitters in Digestive Diseases
- Metagenomic Analysis of the Stool Microbiome in Patients Receiving Allogeneic Stem Cell Transplantation: Loss of Diversity Is Associated with Use of Systemic Antibiotics and More Pronounced in Gastrointestinal Graft-versus-Host Disease
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