LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies
Explore this paper's citation graph
Summary
It is found that polygenicity accounts for the majority of the inflation in test statistics in many GWAS of large sample size, and the LD Score regression intercept can be used to estimate a more powerful and accurate correction factor than genomic control.
- Type
- article
- Published
- 2014-02-21
- Cited by
- 5,242
- References
- 61
- Access
- Open access
- OpenAlex
- https://openalex.org/W2153860431
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6322006
Keywords
Confounding, Biology, Genome-wide association study, Regression, Genetic association
References
- Population Structure and Eigenanalysis
- 骨髄異形成症候群のgenome-wide analysis
- Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
- A mixed-model approach for genome-wide association studies of correlated traits in structured populations
- Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data.
- The genome-wide patterns of variation expose significant substructure in a founder population.
- Meta-analysis of genome-wide association studies with overlapping subjects.
- Classic selective sweeps were rare in recent human evolution
- The structure and evolution of centromeric transition regions within the human genome
- Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review.
- Linkage disequilibrium in humans: models and data.
- Genomic Control for Association Studies
- Estimating R 2 Shrinkage in Multiple Regression: A Comparison of Different Analytical Methods
- Widespread Genomic Signatures of Natural Selection in Hominid Evolution
- GCTA: a tool for genome-wide complex trait analysis.
- Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection.
- Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
- Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
- A Comparison of Different Analytical Methods for the Determination of Potassium and Phosphorus in Soil Based on Field Experiments
- A mega-analysis of genome-wide association studies for major depressive disorder
Cited by
- Genetics: From Molecule to Society.
- Genome-wide association study identifies four novel loci associated with Alzheimer’s endophenotypes and disease modifiers
- A rare splice donor mutation in the haptoglobin gene associates with blood lipid levels and coronary artery disease
- Genome-wide association study of Hirschsprung disease detects a novel low-frequency variant at the RET locus
- From Mendel to quantitative genetics in the genome era: the scientific legacy of W. G. Hill
- Genetics of Eating Disorders: What the Clinician Needs to Know.
- Genome‐wide association study of schizophrenia in Ashkenazi Jews
- Mixed Ancestry and Disease Risk Transferability
- Polygenic Scores in Epidemiology: Risk Prediction, Etiology, and Clinical Utility
- The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders
- Partitioning heritability by functional annotation using genome-wide association summary statistics
- A Fast Method that Uses Polygenic Scores to Estimate the Variance Explained by Genome-wide Marker Panels and the Proportion of Variants Affecting a Trait.
- Age-Dependent Pleiotropy Between General Cognitive Function and Major Psychiatric Disorders
- Phenome-wide analysis of genome-wide polygenic scores
- Efficient Bayesian mixed model analysis increases association power in large cohorts
- The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic Stress Disorder Enters the Age of Large-Scale Genomic Collaboration
- A visual analytics approach to understanding cycling behaviour
- Genetics of disease: Associations with depression
- Biological Insights From 108 Schizophrenia-Associated Genetic Loci
- Rare coding variants and X-linked loci associated with age at menarche
Related papers
- The first broad replication study of SNPs and a pilot genome‐wide association study for androgenetic alopecia in Asian populations
- GWAS summary-based pathway analysis correcting for the genetic confounding impact of environmental exposures
- Genome-wide association studies in aging-related processes such as diabetes mellitus, atherosclerosis and cancer.
- Gene and pathway-based second-wave analysis of genome-wide association studies
- The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes
- A genome-wide association study links small-vessel ischemic stroke to autophagy
- Gene set analysis and network analysis for genome-wide association studies.
- Current opportunities and challenges: genome‐wide association studies on pigmentation and skin cancer
- Statistical methods for genome-wide association studies.
- Genome-wide association studies have problems due to confounding: Are family-based designs the answer?